879326-76-8

Usage

Uses

Used in Organic Chemistry:
5-IODO-PYRIDINE-3-CARBALDEHYDE is used as an intermediate in the synthesis of more complex chemical compounds. Its unique structure and functional groups make it a key component in the creation of a wide range of molecules.
Used in Pharmaceutical Industry:
5-IODO-PYRIDINE-3-CARBALDEHYDE is used as a building block for the development of new pharmaceuticals. Its reactivity and versatility in chemical reactions allow for the creation of novel drug candidates with potential therapeutic applications.
Used in Research and Development:
In the field of research and development, 5-IODO-PYRIDINE-3-CARBALDEHYDE is used as a reactant in various substitution and conjugation reactions. Its properties make it an essential tool for exploring new chemical pathways and discovering innovative compounds.
Used in Material Science:
5-IODO-PYRIDINE-3-CARBALDEHYDE is employed in the synthesis of new materials with unique properties. Its involvement in the formation of these materials can lead to advancements in areas such as electronics, energy storage, and advanced materials for various industries.

InChI:InChI=1/C6H4INO/c7-6-1-5(4-9)2-8-3-6/h1-4H

Upstream product

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• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 4: Core Fragments with Two Halide Leaving Groups Featuring Side Chains of Proteinogenic Amino Acids

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two halide leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. The use of para-bromo iodoarene core fragments resolved the issue of hydrolysis during cross-coupling that was observed when using triflate as a leaving group. We report a complete set of para-bromoiodoarene core fragments decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr and Val). In order to be compatible with general cross-coupling conditions, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks.

A Modular Synthesis of Teraryl-Based α-Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using pyridine containing boronic acid building blocks to increase the water solubility. Following our initial publication in which we have introduced the methodology in combination with sequential Pd-catalyzed cross-coupling for teraryl assembly, we can now report a complete set of pyridine based boronic acid building blocks decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr, Val) to complement the core fragment set. For a representative set of teraryls we have studied the influence of the pyridine rings on the solubility of the assembled oligoarenes.