879374-50-2Relevant articles and documents
Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222
Rodriquez, Manuela,Terracciano, Stefania,Cini, Elena,Settembrini, Giulia,Bruno, Ines,Bifulco, Giuseppe,Taddei, Maurizio,Gomez-Paloma, Luigi
, p. 423 - 427 (2006)
An alternative route: The fungal metabolite FR235222, a potent inhibitor of mammalian histone deacetylase (HDAC), has been synthesized. Key steps are the preparation of unusual amino acids Ahoda and (2R,4S)-MePro. A 3D model for cyclopeptide inhibitor int