87944-74-9

Usage

Class

Oxadiazole
It belongs to a class of compounds that contain a five-membered heterocyclic ring with nitrogen and oxygen atoms.

Structure

5-methyl-3-(2-methylphenyl)
The compound has a methyl group at the 5th position and a 2-methylphenyl group at the 3rd position.

Applications

Pharmaceutical research
The compound is used in the field of pharmaceutical research due to its potential biological activities.

Biological activities

Antimicrobial, anti-inflammatory, and antitumor properties
The compound has shown potential in fighting infections, reducing inflammation, and combating cancer.

Unique molecular structure

Reactivity and synthetic interest
The compound's molecular structure and reactivity make it an interesting target for synthetic and medicinal chemistry studies.

Upstream product

• 40312-14-9 (Z)-N'-hydroxy-2-methylbenzamidine 
• 88303-26-8 O-Acetyl-ortho-tolylamidoxime 
• 88303-26-8 C₁₀H₁₂N₂O₂ 
• 2033-24-1 cycl-isopropylidene malonate 
• 40312-14-9 N'-hydroxy-2-methylbenzamidine 
• 529-19-1 2-Methylbenzonitrile 
• 91667-96-8 N-hydroxy-2-methyl-benzamidine 
• 108-24-7 acetic anhydride 
• 127-19-5 N,N-dimethyl acetamide 

Downstream Products

• 3839-22-3 2-cyanobenzoic acid 

Relevant academic research and scientific papers

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Efficient Synthesis of Functionalized Indene Derivatives via Rh(III)-Catalyzed Cascade Reaction between Oxadiazoles and Allylic Alcohols

A highly efficient rhodium(III)-catalyzed synthesis of novel functionalized indene derivatives has been achieved via C?H activation/intramolecular aldol condensation. This cascade reaction is an atom economical protocol which could be further applied to build more complex compounds. (Figure presented.).

A novel, one-pot, three-component synthesis of 1,2,4-oxadiazoles under microwave irradiation and solvent-free conditions

A novel synthesis of 3,5-disubstituted 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and Meldrum's acids under microwave irradiation and solvent-free conditions in good to excellent yields. Georg

Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst

Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1 - 1.0 equivalents of TBAF in THF for 1 - 24 h at room temperature, alkanoyl- and aroyloxyamidines were converted in high yield to the corresponding 3,5-disubstituted-1,2,4-oxadiazoles. A variety of R and R′ substituents were investigated.

THERMAL REACTIONS OF ARYLAMIDOXIMES

The effect of heat on arylamidoximes, 1a-g, has been examined.When acetic acid was used as solvent, amidoximes, 1a-g, provided three products, viz., 3,5-bis-aryl-1,2,4-oxadiazoles, 2a-g, 3-aryl-5-methyl-1,2,4-oxadiazoles, 3a-g, and a small quantity of an

SYNTHESIS AND SPECTROSCOPIC STUDIES OF 5-METHYL-3-PHENYL- AND 5-METHYL-3-(o-, m-, AND p-TOLYL)-1,2,4-OXADIAZOLES.

Preparation of four 1,2,4-oxadiazoles, 2a-d, from O-acetyl derivatives of benzamidoximes, 1a-d, are reported. Two of them, viz. , 2b,c, were not encountered in the literature. Spectroscopic studies (IR, UV, and **1H NMR) were carried out to learn more abo