879451-59-9

Upstream product

• 79785-97-0 hydrazine hydrate 
• 141-97-9 ethyl acetoacetate 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant academic research and scientific papers

Guanidine hydrochloride catalyzed efficient one-pot pseudo five-component synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) in water

The present methodology describes an efficient, environmentally friendly and simple protocol for the synthesis of some 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives through a one-pot pseudo-five-component reaction of hydrazine hydrate/phenyl hydrazine, ethyl acetoacetate, and various aromatic aldehydes catalyzed by guanidine hydrochloride. This condensation reaction was performed by tandem Knoevenagel–Michael reaction in water under refluxing conditions giving the title compounds in 82–92% yields. Atom economy, simple operation, easy work-up, using inexpensive organocatalyst, high yields in short times, clean transformation, and environmentally benign are some of the important features of this new protocol.

Chickpea leaf exudates: A green Br?nsted acid type biosurfactant for bis(indole)methane and bis(pyrazolyl)methane synthesis

A clean and highly efficient protocol for green synthesis of bis(indole)methanes and bis(pyrazolyl)methanes has been successfully achieved by using a naturally sourced bio-surfactant, chickpea leaf exudates (CLE), as a Br?nsted acid-type catalyst. The rea

Fabrication and characterization of adenine-grafted carbon-modified amorphous ZnO with enhanced catalytic activity

Sustainability has become a countersign and guiding rule for current field of nanocatalysis. Herein, we report a cost-effective, greener, clean, and proficient process for the formation of adenine-grafted carbon-modified amorphous ZnO nanocatalyst (ZnO@AC

SBA-Pr-SO3H-catalyzed synthesis of bispyrazole compounds as anti-bacterial agents and inhibitors of phosphorylated RET tyrosine kinase

Pyrazolone was prepared through the reaction of ethyl acetoacetate and hydrazine hydrate in EtOH at room temperature. Then, bispyrazole derivatives, as attractive biologically active compounds, were synthesized by reacting two equivalents of prepared pyrazolone and one equivalent of aldehyde in the presence of SBA-Pr-SO3H under solvent-free condition at 120?°C. The reaction time was short (3–6?min), while the products’ yield was high (85–97%). Discovery Studio 2.5 (Accelrys Inc, San Diego, CA, USA) was employed to dock the compounds to protein. Molecular docking (GOLD method) studies suggested that pyrazoles bind efficiently to RET kinase. Next, biological activities of the bispyrazoles were tested against some Gram-positive and Gram-negative bacteria and for antifungal activity via the disc-diffusion method. All compounds showed no significant anti-bacterial activities, but two of them showed good activities against Candida albicans. Graphical abstract: [Figure not available: see fulltext.]

Design and Synthesis of Novel Cage like CuFe2O4 Hollow Nanostructure as an Efficient Catalyst for Synthesis of 4,4″-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s

Abstract: Cage like CuFe2O4 hollow nanostructure has been synthesized successfully using hard template method under the hydrothermal condition. Cu(NO3)2·6H2O, Fe(NO3)2·9H2/

Glycerol assisted eco-friendly strategy for the facile synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) and 2-aryl-2,3-dihydroquinazolin-4(1H)-ones under catalyst-free conditions

Abstract: This article describes glycerol mediated eco-friendly approaches for the convenient access of structurally diverse 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) and 2-aryl-2,3-dihydroquinazolin-4(1H)-one motifs under catalyst-free conditions. Prominent advantages include clean processes, atom-efficiency, simplicity of the work-up, neutral conditions, low-cost reaction medium, excellent product yield and solvent reusability, in addition to relatively shorter reaction times. Graphical Abstract: [Figure not available: see fulltext.]

N-Methylimidazolium perchlorate as a new ionic liquid for the synthesis of bis(pyrazol-5-ol)s under solvent-free conditions

N-Methylimidazolium perchlorate ([MIm]ClO4) was synthesized and some of its physico-chemical properties, such as density, surface tension were investigated. A thermo gravimetric analysis (TGA) and solvent performance were also studied. The resu

A rapid, efficient, and high-yielding synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives catalyzed by 12-tungstophosphoric acid (H3PW12O40)

A fast, green, and efficient method for high-yielding synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ols) by one-pot reaction of two equivalents of 3-methyl-1H-pyrazol-5(4H)-one with aryl aldehydes, using 12-tungstophosphoric acid (H3PW12O40) as an effective and inorganic catalyst is described. The catalyst is inexpensive and readily available and can be recovered conveniently and reused efficiently such that a considerable catalytic activity still could be achieved after the tenth run. Compared to the other methods, the present methodology offers several advantages such as excellent yields, short reaction times, and mild reaction conditions with an easy work-up.

Synthesis of 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives in water

An environmentally friendly and simple method for the synthesis of some 4,4′-(arylmethylene)bis(3-methyl-1H-pyrazol-5-ol) derivatives via a one-pot pseudo five-component reaction of hydrazine hydrate, ethyl acetoacetate and aldehydes in water using pyridine trifluoroacetate or acetic acid at 70 °C is reported.