879480-42-9Relevant academic research and scientific papers
Influence of structural changes in ferrocene phosphane aminophosphane ligands on their catalytic activity
?ebesta, Radovan,?kvorcová, Andrea
, p. 1898 - 1902 (2009)
New phosphane aminophosphane ligands based on [3]ferrocenophane skeleton were synthesized using a direct double lithiation followed by phosphanylation. Influence of ligand structure on catalytic performance was evaluated by performing a series of Pd-catalyzed allylic substitution on different substrates. Enantioselectivities up to 55% ee were obtained with bridged ligand compared to 33% ee with analogous non-bridged BoPhoz ligand.
Br?nsted acid and Pd-PHOX dual-catalysed enantioselective addition of activated C-pronucleophiles to internal dienes
Park, Sangjune,Adamson, Nathan J.,Malcolmson, Steven J.
, p. 5176 - 5182 (2019/05/24)
We describe the development of Pd-PHOX-catalysed enantioselective couplings of internal dienes with malononitrile and other activated C-pronucleophiles. Reactions are dramatically accelerated by the addition of Et3N·HBArF4 as a Br?nsted acid co-catalyst, enabling a suite of products bearing a variety of alkyl substituents at the stereogenic carbon to be prepared. A series of mechanism-oriented experiments reveal key aspects of the catalytic cycle and the importance of the non-coordinating BArF4 counterion in not only promoting reactions of internal dienes but also additions of previously unreactive nucleophiles towards terminal dienes.
