87949-14-2Relevant academic research and scientific papers
Nickel-catalyzed Chan-Lam cross-coupling: Chemoselective: N -arylation of 2-aminobenzimidazoles
Kumar, K. Anil,Kannaboina, Prakash,Rao, D. Nageswar,Das, Parthasarathi
, p. 8989 - 8997 (2016/10/05)
A complementary set of Ni- and Cu-based catalyst systems for the selective N-arylation of 2-aminobenzimidazoles have been developed. Selective N-arylation of the primary amine (C-NH2) group was achieved by Ni-catalyzed, boronic acid promoted cr
Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole
Beyer, Astrid,Castanheiro, Thomas,Busca, Patricia,Prestat, Guillaume
, p. 2433 - 2436 (2015/08/24)
Unprecedented CuI/CuII-assisted tandem catalysis allowing an Ullmann/Chan-Evans-Lam sequence was achieved. This three-component, one-pot reaction triggered by a change in the oxidation state of the metal leads to the selective N1,N3-diarylation of 3-aminopyrazole. This new method should be a valuable tool for small-molecule drug discovery that requires suitable regio- and/or chemoselective strategies for the N-arylation of nitrogen-containing heterocycles. Tandem power: The first assisted tandem copper-catalyzed process, triggered by a change in the oxidation state of the metal, is developed to allow a one-pot Ullman/Chan-Evans-Lam sequence leading to the selective N1,N3-diarylation of 3-aminopyrazole.
