87959-13-5

Upstream product

• 84186-34-5 α-(3-indolyl) N-phenyl nitrone 
• 105-53-3 diethyl malonate 
• 84186-34-5 C-(3-indolyl)-N-phenylnitrone 
• 996-82-7 sodium diethylmalonate 
• 487-89-8 Indole-3-carboxaldehyde 

Downstream Products

• 87959-01-1 (E)-3-[(1H-Indol-3-yl)-phenyl-amino]-acrylic acid ethyl ester 
• 84186-47-0 ethyl β,β-dipropionate 
• 87959-12-4 ethyl α-ethoxycarbonyl-β-propenoate 

Relevant academic research and scientific papers

The stereoselective synthesis of highly functionalized tertiary 3-aminoindoles/anilines or dihydropyrroles from C-(3-indolyl)-N-aryl and C,N-diaryl nitrones

We report on the novel properties of nitrones including their transformations via reactions with sodium malonates to give functionalized stereodefined derivatives of tertiary 3-aminoindoles or anilines, as well as fully-substituted dihydropyrroles. The ou

REACTION OF α-3-INDOLYL NITRONES WITH MALONIC ESTERS, INCLUDING MIGRATION OF THE INDOLE RESIDUE

The reaction of α-(3-indolyl) N-aryl(alkyl) nitrones with malonic and methylmalonic esters leads to the formation of derivatives of 3-aminoindole, i.e., the esters of β-N-(3-indolyl)-N-aryl(alkyl)aminopropenoic acids.The reaction was extended to 3-indolyl nitrones differing in the substituents at the nitrogen atom and at position 2 of the indole ring.