879615-68-6

Basic information

• Product Name: Propanamide, 2-bromo-N-(3-chloro-4-cyanophenyl)-2-methyl-
• CAS NO: 879615-68-6
• Molecular Formula: C11H10BrClN2O
• Molecular Weight: 301.57
• Mol File: 879615-68-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-bromo-N-(3-chloro-4-cyanophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-bromo-N-(3-chloro-4-cyanophenyl)-2-methyl-(879615-68-6)
• EPA Substance Registry System: Propanamide, 2-bromo-N-(3-chloro-4-cyanophenyl)-2-methyl-(879615-68-6)

Safety Data

• Hazardous Substances Data: 879615-68-6(Hazardous Substances Data)

Upstream product

• 2052-01-9 2-bromo-2-methylpropionic acid 
• 20925-27-3 4-amino-2-chlorobenzonitrile 
• 20769-85-1 2-bromoisobutyric acid bromide 

Downstream Products

• 1259327-70-2 N,N-dibenzyl-3-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]benzenesulfonamide 

Relevant articles and documents

N-aromatic amide compound and preparation method and application thereof

The invention relates to N-aromatic amide compounds represented by general formulas (I) and (II), a preparation method thereof, a pharmaceutical composition and a pharmaceutical preparation containingthe compound represented by the general formula (I) or (II), and applications of the compounds represented by the general formulas (I) and (II) in preparation of drugs used for treating androgen-related diseases. The definitions of R1, R2, R3, R4, R5, R6, W1, W2, W3, W4 and W5 in the general formulas are the same as those in the specifications. The compounds of the general formulas (I) and (II) are capable of binding to androgen receptors, have activity against androgens and degrade androgen receptors. The compound can be used for treating various androgen-related diseases such as prostate cancer, benign prostatic hyperplasia, breast cancer, bladder cancer, ovarian cancer and the like alone or as a composition, and can also be used for treating diseases such as acnes, hirsutism, alopeciaand the like.

NOVEL IMIDAZOLIDINE DERIVATIVE AND USE THEREOF

According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, -ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a