879682-85-6Relevant academic research and scientific papers
Ligand effects in the synthesis of N-heterocycles by intramolecular Heck reactions
Cropper, Emma L.,White, Andrew J. P.,Ford, Agnes,Hii, King Kuok
, p. 1732 - 1735 (2007/10/03)
Chemo- and regioselectivity of intramolecular Heck reactions are dependent on the type of ligand employed. Six- to eight-membered benzolactams are produced in good yields using PPh3 as ligand. In contrast, a biaryl coupling occurred preferentially under ligandless conditions to form a dihydrophenanthridine product. Conformations of the seven- and eight-membered benzolactams in the solid state were examined by X-ray crystallography.
