87982-83-0

Upstream product

• 153277-55-5 (S)-(+)-N-pentylidene-p-toluenesulfinamide 
• 503819-47-4 [1R,(S)S]-N-{[(S)-2-(p-toluenesulfinyl)benzyl]pentyl}-p-toluenesulfinamide 
• 10381-68-7 (S)-2-methyl-1-(p-tolylsulfinyl)benzene 
• 852332-84-4 (S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene 
• 852332-94-6 [1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide 
• 503819-59-8 (1R)-1-{(S)-2-[p-toluenesulfinyl]benzyl}pentylamine 
• 95-46-5 2-methylphenyl bromide 
• 110-62-3 pentanal 

Relevant academic research and scientific papers

Synthesis of optically pure 1,2-diaryl- and 1,2-alkylaryl-1,2-amino sulfides

The reactions of the lithium (S)-α-(methylthio)-2-(p-toluenesulfinyl) benzyl carbanion with (S)-N-p-tolylsulfinyl aldimines evolve in a completely stereoselective manner providing a one-step synthesis of enantiomerically pure anti-1,2-disubstituted 1,2-am

Facile synthesis of optically pure 1,2-diaryl (and 1-alkyl-2-aryl) ethyl and propylamines

(Figure presented) A concise high-yielding route to synthetically useful 1,2-diaryl (and 1-alkyl-2-aryl) ethyl and propylamines in high enantiomeric purity is described. The key step of this route is the completely stereoselective addition of lithium (R)-ortho-(p-toluenesulfinyl)benzylic carbanions to (S).N.p-toluenesulfinylimines, which takes place in very high or quantitative yields. N-Desulfinyiation and C-desulfinylation of the resulting adducts can be achieved with no loss of optical purity employing conventional methods (TFA and Raney-Ni, respectively).