87985-79-3Relevant academic research and scientific papers
Carbon-fluorine bond activation of perfluorinated arenes with Cp2*ZrH2
Kraft, Bradley M,Jones, William D
, p. 132 - 140 (2007/10/03)
Reaction of Cp2*ZrH2 (Cp*, pentamethylcyclopentadienyl) with excess hexafluorobenzene produces a mixture of Cp2*ZrHF, C6F5H and Cp2*Zr(C6F5)H in ca. 2:1:1 ratio. Reaction of Cp2*ZrH2 with excess C6F5H produces a mixture of Cp2*ZrHF, Cp2*Zr(C6F5)H, Cp2*Zr(o-C6F4H)H, p-C6F4H2, and o-C6F4H2 with preferred ortho aromatic C-F activation. Dual mechanisms are proposed for the formation of ArFH and Cp2*Zr(ArF)H species.
Aliphatic and aromatic carbon-fluorine bond activation with Cp*2ZrH2: Mechanisms of hydrodefluorination
Kraft,Lachicotte,Jones
, p. 10973 - 10979 (2007/10/03)
Cp*2ZrH2 (1) (Cp* = pentamethylcyclopentadienyl) reacts with primary, secondary, and tertiary monofluorinated aliphatic hydrocarbons to give Cp*2ZrHF (2) and/or Cp*2ZrF2 and alkane quantitatively through a radical chain mechanism. The reactivity of monofluorinated aliphatic C-F bonds decreases in the order 1° > 2° > 3°. The rate of hydrodefluorination was also greatly reduced with -CF2H and -CF3 groups attached to the hydrocarbon. An atmosphere of H2 is required to stabilize 1 against C-H activation of the Cp*-methyl groups and subsequent dimerization under the thermal conditions employed in these reactions. Reaction of 1 with fluorobenzene cleanly forms a mixture of Cp*2ZrHF, benzene, and Cp*2Zr(C6H5)F. Detailed studies indicate that radicals are not involved in this aromatic C-F activation reaction and that dual hydrodefluorination pathways are operative. In one mechanism, hydridic attack by Cp*2ZrH2 on the aromatic ring and fluoride abstraction is involved. In the second mechanism, an initial ortho C-H activation occurs, followed by β-fluoride elimination to generate a benzyne complex, which then inserts into the zirconium-hydride bond.
