87988-03-2Relevant academic research and scientific papers
POTASSIUM CHANNEL MODULATORS
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Page/Page column 21, (2011/06/19)
Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
Kaizerman, Jacob A.,Aaron, Wade,An, Songzhu,Austin, Richard,Brown, Matt,Chong, Angela,Huang, Tom,Hungate, Randall,Jiang, Ben,Johnson, Michael G.,Lee, Gary,Lucas, Brian S.,Orf, Jessica,Rong, Minqing,Toteva, Maria M.,Wickramasinghe, Dineli,Xu, Guifen,Ye, Qiuping,Zhong, Wendy,McMinn, Dustin L.
scheme or table, p. 4607 - 4610 (2010/10/02)
Pyridopyridazine antagonists of the hedgehog signaling pathway are described. Designed to optimize our previously described phthalazine smoothened antagonists, a representative compound eliminates a PXR liability while retaining potency and in vitro metab
A new and convenient synthesis of 3-aryl-3-hydroxyisoindol-1-ones and their aza analogs
Saito,Sakamoto,Kikugawa
, p. 221 - 224 (2007/10/03)
A simple and convenient synthesis of 3-aryl-3-hydroxyisoindol-1-ones and their aza analogs is described. The utility of this synthesis is demonstrated by the preparation of 4-arylphthalazinones and their aza analogs.
New synthesis of pyrido[2,3-d] and [3,2-d]oxazines
Fahmy, Amin F.,Sauer, Juergen,Youssef, Mohamed Salah K.,Halim, Mohamed Said Abdel,Hassan, Mamdouh A.
, p. 2871 - 2886 (2007/10/03)
N-Hydroxyquinolinimide 1 reacts with each of aromatic arnines, hydrazine hydrate and aromatic hydrocarbons to give arylcarbamoyl pyridines 2, pyrrolopyridines 3, pyridopyridazines 4 and pyridooxazinones 5 and 6. The heterocycles 5 and 6 can be transformed
