879887-28-2

Usage

Uses

Used in Organic Synthesis:
1(2H)-Isoquinolinone, 6-bromo-2-ethyl-3,4-dihydrois used as a building block in the synthesis of various organic compounds. Its unique structure, including the bromine atom and dihydro-3,4 ring, allows for the creation of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1(2H)-Isoquinolinone, 6-bromo-2-ethyl-3,4-dihydrois utilized as a starting material for the development of new drugs. Its potential biological activity and pharmacological properties make it a promising candidate for further research and development, particularly in the areas of medicinal chemistry and drug design.

Upstream product

• 147497-32-3 6-bromo-3,4-dihydroisoquinolin-1(2H)-one 
• 75-03-6 ethyl iodide 

Relevant academic research and scientific papers

CDK6 inhibitor of pyrimidine benzo six-membered ring mother nucleus as well as preparation method and application of CDK6 inhibitor

The invention discloses a CDK6 inhibitor of a pyrimidine benzo six-membered ring mother nucleus and a preparation method and application of the CDK6 inhibitor, the compound structure of the CDK6 inhibitor is shown as a formula (C), and A is selected from O, C (O) or-NR1; R1 is selected from hydrogen or C1-C8 alkyl; B is selected from O or C; X is selected from C, C (O) or-NR2; R2 is selected from hydrogen or C1-C8 alkyl; Y is selected from C (O) or (CH2) n; n is 0 or 1; and Z is selected from hydrogen, C1-C8 alkyl or-C (O) OC1-C3. The invention also discloses a preparation method and application of the compound.

BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. A compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signalling pathway, and in particular, has a good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by TLR family and the TLR-related signalling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.

Sulfonamide bicyclic compounds

The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide (β-AP) production.