879893-72-8

Basic information

• Product Name: Pyridine, 2-methoxy-5-(3-phenylpropyl)-
• CAS NO: 879893-72-8
• Molecular Formula: C15H17NO
• Molecular Weight: 227.306
• Mol File: 879893-72-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-methoxy-5-(3-phenylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-methoxy-5-(3-phenylpropyl)-(879893-72-8)
• EPA Substance Registry System: Pyridine, 2-methoxy-5-(3-phenylpropyl)-(879893-72-8)

Safety Data

• Hazardous Substances Data: 879893-72-8(Hazardous Substances Data)

Upstream product

• 637-59-2 1-Bromo-3-phenylpropane 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 104-52-9 phenylpropyl chloride 
• 13473-01-3 5-chloro-2-methoxypyridine 
• 329685-40-7 4,4,5,5-tetramethyl-2-(3-phenylpropyl)-[1,3,2]dioxaborolane 
• 300-57-2 allylbenzene 

Relevant articles and documents

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling

Despite their importance, the synthesis of alkylated heterocycles from the cross-coupling of Lewis basic nitrogen heteroaryl halides with alkyl halides remains a challenge. We report here a general solution to this challenge enabled by a new collection of ligands based around 2-pyridyl-N-cyanocarboxamidine and 2-pyridylcarboxamidine cores. Both primary and secondary alkyl halides can be coupled with 2-, 3-, and 4-pyridyl halides as well as other more complex heterocycles in generally good yields (41 examples, 69% ave yield).

Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

A constant-current electrochemical method for reducing catalytic nickel complexes in sp2-sp3 cross-electrophile coupling reactions has been developed. The electrochemical reduction provides reliable nickel catalyst activation and turnover and offers a tunable parameter for reaction optimization, in contrast to more standard activated metal powder reductants. The electrochemical reactions give yields (i.e., 51-86%) and selectivities as high or superior to those using metal powder reductants and provide access to a wider substrate scope.

Inhibition of cancer-associated mutant isocitrate dehydrogenases: Synthesis, structure-activity relationship, and selective antitumor activity

Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant enzymes catalyze the reduction of α-ketoglutaric acid to d-2-hydroxyglutaric acid (D2HG), leading to cancer initiation. Several 1-hydroxypyridin-2-one compounds were identified to be inhibitors of IDH1(R132H). A total of 61 derivatives were synthesized, and their structure-activity relationships were investigated. Potent IDH1(R132H) inhibitors were identified with Ki values as low as 140 nM, while they possess weak or no activity against WT IDH1. Activities of selected compounds against IDH1(R132C) were found to be correlated with their inhibitory activities against IDH1(R132H), as well as cellular production of D2HG, with R2 of 0.83 and 0.73, respectively. Several inhibitors were found to be permeable through the blood-brain barrier in a cell-based model assay and exhibit potent and selective activity (EC50 = 0.26-1.8 μM) against glioma cells with the IDH1 R132H mutation.