879898-99-4Relevant academic research and scientific papers
Chiral synthesis of (+)-febrifugine and (-)-isofebrifugine by means of samarium diiodide-promoted carbon-nitrogen bond cleavage reaction
Katoh, Miho,Matsune, Ryuichiro,Honda, Toshio
, p. 189 - 204 (2007/10/03)
(+)-Febrifugine, a potential anti-malarial piperidine alkaloid, was synthesized from (4S)-hydroxyproline methyl ester, stereoselectively, where a samarium diiodide-promoted carbon-nitrogen bond cleavage reaction was involved as a key reaction. A stereocon
Stereocontrolled synthesis of a potent antimalarial alkaloid, (+)-febrifugine
Katoh, Miho,Matsune, Ryuichiro,Nagase, Hiromasa,Honda, Toshio
, p. 6221 - 6223 (2007/10/03)
A novel and stereocontrolled synthetic path to a potential antimalarial piperidine alkaloid, (+)-febrifugine, was established by employing a reductive deamination of a proline derivative with samarium diiodide, as a key step. A novel and stereocontrolled
