87992-97-0Relevant academic research and scientific papers
Oxidation of the inert sp3C-H bonds of tetrahydroisoquinolines through C-H activation relay (CHAR): construction of functionalized isoquinolin-1-ones
Yuan, Yuan,Zhang, Shuwei,Sun, Zheng,Su, Yichun,Ma, Qiyuan,Yuan, Yu,Jia, Xiaodong
, p. 3347 - 3350 (2021/04/07)
A TBN/O2-initiated oxidation of the relatively inert 3,4-C-H bonds of THIQs was accomplished, in which the existence of an α-phosphoric ester group is crucial to enable dioxygen trapping and intramolecular HAT (C-H activation relay,CHAR), reali
α-Substituted Phosphonates. 43. Synthesis and Reactivity of 1,2,3,4-Tetrahydroisoquinolin-1-phosphonates
Gross, H.,Ozegowski, S.
, p. 437 - 445 (2007/10/02)
N-Alkyl- and N-arylsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonates 1 have been synthesized from the corresponding 3,4-dihydroisochinoliniumbromides 7 and triethylphosphite.The N-unsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonate 10 is available starting from the 1,2,3,4-tetrahydroisochinolin-1-phosphonic acid by esterification with triethylformate and splitting off the formyl group of the primarily formed N-formyl derivative 14. - N-Quarternated tetrahydroisochinolines 19 and the 1-phosphorylated derivatives 17, respectively react with triethylphosphite in an unexpected way by dealkylation and not by splitting off the isochinolinring. - By Horner-synthesis with 1 the 1-aralkylidene-isochinolines 23 are available in moderate yields.
