87993-00-8Relevant academic research and scientific papers
A preparation method of the compound α - phosphoramidate
-
Paragraph 0047; 0048; 0049, (2017/11/01)
The invention discloses a preparation method of an alpha-phosphoramidate compound. The preparation method comprises the following steps: by taking low-molecular alcohol as a reaction solvent and taking N-phenyl-1,2,3,4-tetrahydroisoquinoline and dialkyl p
Iron-catalyzed aerobic oxidative phosphonation of N-aryl tetrahydroisoquinolines
Cai, Junjie,Liu, Yingle,Jiang, Yan,Yang, Yi
supporting information, p. 1068 - 1073 (2017/09/08)
We report herein a novel and efficientmethod for iron-catalyzed aerobic oxidative phosphonation of N-aryl tetrahydroisoquinolines for the synthesis of biologically interesting α-aminophosphonates. This new C–P bond formation reaction features the employme
Catalytic amounts of triarylaminium salt initiated aerobic oxidative coupling of N-aryl tetrahydroisoquinolines
Huo, Congde,Wang, Cheng,Wu, Mingxia,Jia, Xiaodong,Wang, Xicun,Yuan, Yong,Xie, Haisheng
, p. 3123 - 3128 (2014/05/06)
A novel stable radical cation triarylaminium salt able to induce aerobic oxidative α-C-H functionalization of tertiary amines in catalytic amounts has been developed. The reaction is performed in the absence of any other additives under mild conditions an
α-Substituted Phosphonates. 43. Synthesis and Reactivity of 1,2,3,4-Tetrahydroisoquinolin-1-phosphonates
Gross, H.,Ozegowski, S.
, p. 437 - 445 (2007/10/02)
N-Alkyl- and N-arylsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonates 1 have been synthesized from the corresponding 3,4-dihydroisochinoliniumbromides 7 and triethylphosphite.The N-unsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonate 10 is available starting from the 1,2,3,4-tetrahydroisochinolin-1-phosphonic acid by esterification with triethylformate and splitting off the formyl group of the primarily formed N-formyl derivative 14. - N-Quarternated tetrahydroisochinolines 19 and the 1-phosphorylated derivatives 17, respectively react with triethylphosphite in an unexpected way by dealkylation and not by splitting off the isochinolinring. - By Horner-synthesis with 1 the 1-aralkylidene-isochinolines 23 are available in moderate yields.
