87993-01-9Relevant academic research and scientific papers
Thiourea-Catalyzed Cross-Dehydrogenative Coupling of C(sp3)–H with Diethyl Phosphite
Gu, Kai,Zhang, Zhiguo,Bao, Zongbi,Xing, Huabin,Yang, Qiwei,Ren, Qilong
supporting information, p. 3939 - 3942 (2016/08/24)
The efficient thiourea-catalyzed cross-dehydrogenative coupling of C(sp3)–H with diethyl phosphite by using tert-butyl peroxide as a terminal oxidant was explored. This protocol further expands the application scope of H-bond donors and also pr
α-Substituted Phosphonates. 43. Synthesis and Reactivity of 1,2,3,4-Tetrahydroisoquinolin-1-phosphonates
Gross, H.,Ozegowski, S.
, p. 437 - 445 (2007/10/02)
N-Alkyl- and N-arylsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonates 1 have been synthesized from the corresponding 3,4-dihydroisochinoliniumbromides 7 and triethylphosphite.The N-unsubstituted 1,2,3,4-tetrahydroisochinolin-1-phosphonate 10 is available starting from the 1,2,3,4-tetrahydroisochinolin-1-phosphonic acid by esterification with triethylformate and splitting off the formyl group of the primarily formed N-formyl derivative 14. - N-Quarternated tetrahydroisochinolines 19 and the 1-phosphorylated derivatives 17, respectively react with triethylphosphite in an unexpected way by dealkylation and not by splitting off the isochinolinring. - By Horner-synthesis with 1 the 1-aralkylidene-isochinolines 23 are available in moderate yields.
