87997-28-2

Upstream product

• 27916-67-2 2,3,4-tris(benzyloxy)benzaldehyde 
• 55020-64-9 1,2,3-tris-benzyloxybenzene 
• 87-66-1 2-hydroxyresorcinol 
• 1609113-44-1 benzyl 2,3,4-tris(benzyloxy)benzoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 87997-29-3 1,2,3-tribenzyloxy-4-methoxybenzene 
• 642-96-6 1,2,3,4-tetrahydroxybenzene 
• 1618645-23-0 2,3,4-trihydroxyphenyl acetate 
• 1618645-24-1 1,3,4-trihydroxyphenyl acetate 
• 1618645-01-4 2,3,4-tris(benzyloxy)phenyl acetate 
• 87997-33-9 2'-hydroxy-4',5-dimethoxy-2,3,3',4-tetrabenzyloxychalcone 
• 87997-32-8 2,3,4-tribenzyloxy-5-methoxybenzaldehyde 
• 87997-31-7 2,3,4-trihydroxy-5-methoxy-benzaldehyde 
• 87997-30-6 1-methoxy-2,3,4-trihydroxybenzene 
• 69422-80-6 ubiquinol-3 
• 95778-33-9 1,2,3,4-tetramethoxy-5-methyl-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)benzene 
• 35896-58-3 2,3,4,5-tetramethoxytoluene 
• 21450-56-6 1,2,3,4-tetramethoxybenzene 

Relevant academic research and scientific papers

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

The synthesis and the assessment of the anti-HIV activity of a set of molecules inspired by the multivalent structures of some naturally-occurring polyphenols (tannins) are reported. Different multibranched scaffolds have been derived from pentaerythritol as the central core which distribute spatially synthetic polyphenolic subunits based on 1-substituted 2,3,4-trihydroxyphenyl moieties. A tetrapodal compound (13b) bearing four N-(2,3,4-trihydroxyphenyl) amide groups, exhibits remarkable selective activity against HIV-1 with EC 50 values in the micromolar scale, in the same range as those reported for the most representative anti-HIV tannins. Preliminary SAR studies emphasize the importance of the 1-substituted 2,3,4-trihydroxyphenyl moiety, the presence of an amide as the linker and the multivalent architecture of these molecules, since the anti-HIV activity increases with the number of polyphenolic moieties. The data support the interest in synthetic polyphenols and represent a promising starting point for further design and development of selective HIV-1 inhibitors.

Synthesis of 1,2,3,4-tetrahydroxybenzenes from biomass-derived carbon

A bioengineered synthesis scheme for the production of 1,2,3,4-tetrahydroxybenzene from a carbon source is provided. Methods of producing 1,2,3,4-tetrahydroxybenzene acid from a carbon source based on the synthesis scheme are also provided. Methods are also provided for converting 1,2,3,4-tetrahydroxybenzene to 1,2,3-trihydroxybenzene by catalytic hydrogenation.

AN ATTEMPT TO ELUCIDATE THE CONSTITUTION OF BRYAQUINONE BY SYNTHESIS

4,9,10-Triacetoxy-3,8-dimethoxy-6H-benzofurobenzopyran (13) was synthesized in 13 steps and found to be non-identical with the leucoacetate of bryaquinone, a constituent of yet unknown structure of Brya ebenus.