88-30-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Nitro-3-(trifluoromethyl)phenol is used as a chemical intermediate in the preparation of bicyclic heteroaryl substituted compounds, which serve as PAR4 inhibitors. These inhibitors have potential applications in the development of drugs for the treatment of various diseases, such as cancer and inflammatory disorders.
Used in Environmental Protection:
4-Nitro-3-(trifluoromethyl)phenol is used as a lamprey killer, which is an environmentally friendly method to control the population of lampreys, a parasitic fish species that can cause significant damage to aquatic ecosystems and commercial fisheries.

Flammability and Explosibility

Notclassified

Purification Methods

Crystallise the nitrophenol from *benzene or from pet ether/*benzene mixture. [Beilstein 6 III 1328.]

InChI:InChI=1/C7H4F3NO3/c8-7(9,10)5-3-4(12)1-2-6(5)11(13)14/h1-3,12H

Upstream product

• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 
• 393-11-3 4-nitro-3-(trifluoromethyl)benzeneamine 
• 384-22-5 2-nitrobenzotrifluoride 
• 98-17-9 3-Trifluoromethylphenol 
• 118-83-2 5-chloro-2-nitrotrifluoromethylbenzene 

Downstream Products

• 445-04-5 4-amino-3-(trifluoromethyl)-phenol 
• 19125-94-1 Bis<4-nitro-3-trifluormethyl-phenyl>-oxalat 
• 21315-03-7 4-cyclopropylmethoxy-1-nitro-2-trifluoromethylbenzene 
• 62100-47-4 2-Methyl-2-(4-nitro-3-trifluoromethyl-phenoxy)-propionic acid 
• 344-39-8 4-methoxy-1-nitro-2-(trifluoromethyl)benzene 
• 1027422-94-1 2-(3-{2-[3-(4-nitro-3-trifluoromethyl-phenoxy)-prop-1-ynyl]-phenyl}-prop-2-ynyloxy)-tetrahydro-pyran 
• 158583-72-3 4-amino-2-(piperidin-1'-ylmethyl)-5-trifluoromethylphenol 
• 62100-51-0 2-Methyl-2-(4-nitro-3-trifluoromethyl-phenoxy)-propionamide 
• 52806-53-8 hydroxyflutamide 
• 113405-09-7 <4-nitro-3-(trifluoromethyl)phenoxy>acetic acid 
• 733802-94-3 2,6-dibromo-3-trifluoromethyl-4-nitrophenol 
• 873455-94-8 3-(4-nitro-3-trifluoromethyl-phenoxy)-propane-1,2-diol 
• 630412-84-9 4-(3-Fluoro-benzyloxy)-1-nitro-2-trifluoromethyl-benzene 
• 1217903-45-1 5-(4-nitro-3-trifluoromethylphenoxymethyl)isoxazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Selective Light-Driven Chemoenzymatic Trifluoromethylation/Hydroxylation of Substituted Arenes

The merging of photoredox trifluoromethylation with hybrid P450 BM3 variants has enabled the selective light-driven functionalization of several arenes. This approach capitalizes on the unique photochemical properties of the Ru(II)-diimine photosensitizer

Resourceful treatment method for industrial wastewater generated in production of 5-chloro-2-nitrobenzotrifluoride

The invention provides a resourceful treatment method for industrial wastewater generated in production of 5-chloro-2-nitrobenzotrifluoride. The method is mild in condition, simple to operate and high in safety. The method comprises the following steps: feeding wastewater generated in the production of 5-chloro-2-nitrobenzotrifluoride and FSBA into a container, wherein the feeding mass ratio of the wastewater to the FSBA is 1: (0.5-2); reacting for 1-24 hours at the temperature of 30-100 DEG C under mechanical stirring; and cooling to room temperature, filtering, washing the filter cake with hydrochloric acid, dropwise adding hydrochloric acid into the filtrate until the pH value of the filtrate is 2-3, standing, crystallizing, and filtering to obtain 3-trifluoromethyl-4-nitro-phenol solid.

A practical approach for regioselective mono-nitration of phenols under mild conditions

Cu(NO3)2.3H2O was demonstrated to be an efficient, regioselective and inexpensive nitrating reagent for the synthesis of mono-nitro substituted phenolic compounds. 12 examples of different phenols were examined. Good yields (67-90%) have been achieved. ARKAT-USA, Inc.

Activation and stabilization of aldimines by an ortho-trifluoromethyl substituent in direct vinylogous Mannich-type reactions

Lewis acid catalyzed direct vinylogous Mannich-type reaction with a weak nucleophile dienol, generated in situ by ring-opening and rearrangement of vinyloxiranes, could be demonstrated in excellent yields under mild conditions using benzylidene(4-methoxy-2-trifluoromethyl)aniline (MTMA) as an electrophile. The o-trifluoromethyl substituent can stabilize imines by a steric effect and activate by an electron-withdrawing effect. It proved to be an easily deprotectable protecting group for direct Mannich-type reactions.

Hydroxylation of Nitroarenes with Alkyl Hydroperoxide Anions via Vicarious Nucleophilic Substitution of Hydrogen

Rhone-Poulenc Polska Ltd., ul. Grzybowska 80/82, 00-844 Warszawa, Poland Garbo- and heterocyclic nitroarenes react with anions of tert-butyl and cumyl hydroperoxides in the presence of strong bases to form substituted o- and p-nitrophenols. The reaction usually proceeds in high yields and is of practical value as a method of synthesis and manufacturing of nitrophenols. Orientation of the hydroxylation can be controlled to a substantial extent by selection of the proper conditions. Basic mechanistic features of this process were clarified.