88002-33-9

Basic information

• Product Name: [1,2,4]Triazolo[1,5-a]pyrazin-2-amine
• Synonyms: [1,2,4]Triazolo[1,5-a]pyrazin-2-amine;[1,2,4]Triazolo[1,5-a]pyrazin-2-ylamine
• CAS NO: 88002-33-9
• Molecular Formula: C₅H₅N₅
• Molecular Weight: 135.1267
• Mol File: 88002-33-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 207-208 °C(Solv: 1-butanol (71-36-3))
• Appearance: /
• Density: 1.74±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.63±0.30(Predicted)
• CAS DataBase Reference: [1,2,4]Triazolo[1,5-a]pyrazin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2,4]Triazolo[1,5-a]pyrazin-2-amine(88002-33-9)
• EPA Substance Registry System: [1,2,4]Triazolo[1,5-a]pyrazin-2-amine(88002-33-9)

Safety Data

• Hazardous Substances Data: 88002-33-9(Hazardous Substances Data)

Usage

General Description

[1,2,4]Triazolo[1,5-a]pyrazin-2-amine is a chemical compound with the molecular formula C5H6N6. It is a heterocyclic organic compound that consists of a triazole and a pyrazine ring. [1,2,4]Triazolo[1,5-a]pyrazin-2-amine has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceuticals and bioactive molecules. It has been the subject of research for its potential biological activities, including its possible role as an antifungal or antimicrobial agent. The chemical structure and properties of [1,2,4]Triazolo[1,5-a]pyrazin-2-amine make it an important target for synthetic chemistry and drug discovery efforts.

Upstream product

• 5049-61-6 2-Aminopyrazine 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 
• 86525-11-3 Pyrazin-2-yl-cyanamide 
• 56406-73-6 ethyl[(pyrazin-2-ylamino)carbonothioyl]carbamate 
• 88002-32-8 N-(5-Oxo-Δ²-1,2,4-oxadiazolin-3-yl)-2-pyrazinylamine 
• 88002-29-3 N-(Tetrazolyl-5')-2-pyrazinylamine 
• 88002-31-7 N-(Pyrazinyl-2)-N'-hydroxyguanidine 

Downstream Products

• 1575608-55-7 (2R,3R)-3-((2-(furan-2-yl)phenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-52-4 (2R,3R)-3-((2-(thiophen-2-yl)phenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-50-2 (2R,3R)-3-(2-(4-isopropylphenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-45-5 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-cyanophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-43-3 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-40-0 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methoxyphenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-38-6 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methylphenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-34-2 (2R,3R)-3-(2-(3-isopropylphenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-32-0 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(2,4-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-30-8 (2R,3R)-3-(2-(4-(trifluoromethyl)phenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-27-3 (2R,3R)-3-(2-(3-(trifluoromethyl)phenyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-2-(2,4-difluoro-phenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-25-1 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-bromophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-24-0 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(3-chlorophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-19-3 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-chlorophenyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]piperazine-7(8H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 

Relevant articles and documents

ANNULATED GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W1, W2, W3, W4, W5, W6, L, Q, Rx and u have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.

HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS

Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer or infections.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.