88014-18-0Relevant academic research and scientific papers
THE SYNTHESIS OF SOME ALCOHOLS DERIVED FROM 1,2,3,4-TETRAHYDROISOQUINOLINE AND FROM 1,2,3,4-TETRAHYDROQUINOLINE
Ferles, Miloslav,Silhankova, Alexandra,Kafka, Stanislav,Taufmann, Petr,Motacek, Tomas
, p. 1759 - 1764 (2007/10/02)
Reduction of ethyl ester of ω-(1,2,3,4-tetrahydro-2-isoquinolyl)alkanoic acids IVa-e by means of LiAlH4 was used for the preparation of corresponding primary alcohols Ia-e. 6-(1,2,3,4-tetrahydro-2-isoquinolyl)-1-hexanol (Ie) was also obtained on reduction of ester amide VII.Reduction of 2-(2-hydroxypropanoyl)-1,2,3,4-tetrahydroisoquinoline (V) with LiAlH4 gave secondary alcohol II; in the quinoline series alcohol IIIa was obtained in a similar manner by reduction of ethyl 3-(1,2,3,4-tetrahydro-1-quinolyl)propanoate (IIIb).
