880252-11-9Relevant academic research and scientific papers
Resveratrol analogue containing long conjugated structure as well as preparation method and application thereof
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Paragraph 0042-0050, (2020/11/25)
The present invention discloses a resveratrol analogue containing a long conjugated structure. The compound has a structure represented by a general formula (I), R1 is respectively positioned at any other positions of a ring A and a ring B except the connection position, is monosubstituted or polysubstituted, and represents hydrogen, phenolic hydroxyl, nitryl, saturated alkyl of C1-C4, and unsaturated alkyl of C1-C4; and R2 represents hydrogen, methyl and ethyl. The resveratrol analogue with the conjugated structure has antioxidant activity, and particularly has the effect of resisting DNA oxidative damage. The invention also relates to a preparation method and application of the resveratrol analogue.
Finding more active antioxidants and cancer chemoprevention agents by elongating the conjugated links of resveratrol
Tang, Jiang-Jiang,Fan, Gui-Juan,Dai, Fang,Ding, De-Jun,Wang, Qi,Lu, Dong-Liang,Li, Ran-Ran,Li, Xiu-Zhuang,Hu, Li-Mei,Jin, Xiao-Ling,Zhou, Bo
, p. 1447 - 1457 (2012/05/05)
Resveratrol is the subject of intense research as a natural antioxidant and cancer chemopreventive agent. There has been a great deal of interest and excitement in understanding its action mechanism and developing analogs with antioxidant and cancer chemoprevention activities superior to that of the parent compound in the past decade. This work delineates that elongation of the conjugated links is an important strategy to improve the antioxidant activity of resveratrol analogs, including hydrogen atom- or electron-donating ability in homogeneous solutions and antihemolysis activity in heterogeneous media. More importantly, C3, a triene bearing 4,4′-dihydroxy groups, surfaced as an important lead compound displaying remarkably increased antioxidant, cytotoxic, and apoptosis-inducing activities compared with resveratrol.
