88035-31-8

Basic information

• Product Name: (3S^*,4R^*)-3-<(R^*)-1-tert-butyldimethylsilyloxyethyl>-4-triphenylmethylthio-2-azetidinone
• CAS NO: 88035-31-8
• Molecular Weight: 503.781
• Mol File: 88035-31-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3S^*,4R^*)-3-<(R^*)-1-tert-butyldimethylsilyloxyethyl>-4-triphenylmethylthio-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3S^*,4R^*)-3-<(R^*)-1-tert-butyldimethylsilyloxyethyl>-4-triphenylmethylthio-2-azetidinone(88035-31-8)
• EPA Substance Registry System: (3S^*,4R^*)-3-<(R^*)-1-tert-butyldimethylsilyloxyethyl>-4-triphenylmethylthio-2-azetidinone(88035-31-8)

Safety Data

• Hazardous Substances Data: 88035-31-8(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 75939-72-9 racemic (3S,4R)-3-((R)-1-hydroxyethyl)-4-triphenylmethylthio-2-azetidinone 
• 3695-77-0 triphenylmethanethiol 
• 76899-07-5 (3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one 
• 78963-50-5 (3R,4R)-4-acetoxy-3-<(1R)-(tert-butyldimethylsiloxy)ethyl>-1-(1-methoxycarbonyl-2-methylpropen-1-yl)-azetidin-2-one 
• 75939-73-0 1-(tert-Butyl-dimethyl-silanyl)-3-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-tritylsulfanyl-azetidin-2-one 
• 75939-59-2 (3S,4R)-3-Acetyl-1-(tert-butyl-dimethyl-silanyl)-4-tritylsulfanyl-azetidin-2-one 
• 158250-76-1 1-(tert-Butyl-dimethyl-silanyl)-3-(1-hydroxy-ethyl)-4-tritylsulfanyl-azetidin-2-one 
• 102628-04-6 (3S^*,4R^*)-1-tert-butyldimethylsilyl-3-(1,2-dihydroxy-2-propyl)-4-triphenylmethylthio-2-azetidinone 

Downstream Products

• 87996-94-9 racemic (3S,4R)-1-(allyloxycarbonyl)methyl-3-((R)-1-t-butyldimethylsilyloxyethyl)-4-triphenylmethylthio-2-azetidinone 
• 87996-95-0 racemic (3S,4R)-1-(p-nitrobenzylcarbonyl)methyl-3-((R)-1-t-butyldimethylsilyloxyethyl)-4-triphenylmethylthio-2-azetidinone 
• 92771-90-9 {(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-oxo-4-tritylsulfanyl-azetidin-1-yl}-hydroxy-acetic acid 4-methoxy-benzyl ester 
• 182414-61-5 Succinic acid (R)-1-((5S,6S)-2-allyloxycarbonyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-en-6-yl)-ethyl ester 4-nitro-benzyl ester 
• 182414-58-0 (5S,6S)-6-{(R)-1-[2-(tert-Butyl-diphenyl-silanyloxy)-acetoxy]-ethyl}-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 
• 182414-66-0 (5S,6S)-6-((R)-1-{2-[3,4-Bis-(tert-butyl-diphenyl-silanyloxy)-phenyl]-acetoxy}-ethyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 
• 182414-63-7 (5S,6S)-6-{(R)-1-[3,4-Bis-(tert-butyl-diphenyl-silanyloxy)-benzoyloxy]-ethyl}-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 
• 92772-07-1 p-methoxybenzyl (5R^*,6S^*)-6-<(R^*)-1-hydroxyethyl>-2-(1,3,4-thiadiazol-2-yl)thiomethylpenem-3-carboxylate 
• 92786-58-8 p-methoxybenzyl (5R^*,6S^*)-6-<(R^*)-1-hydroxyethyl>-2-(1-methyl-1H-tetrazol-5-yl)thiomethylpenem-3-carboxylate 
• 92786-59-9 p-methoxybenzyl (5R^*,6S^*)-6-<(R^*)-1-hydroxyethyl>-2-<1-(2-hydroxyethyl)-1H-tetrazol-5-yl>thiomethylpenem-3-carboxylate 
• 92772-03-7 p-methoxybenzyl (5R^*,6S^*)-2-(1-carbamoylmethyl-1H-tetrazol-5-yl)-6-<(R^*)-1-hydroxyethyl>penem-3-carboxylate 
• 92771-92-1 (3S^*,4R^*)-3-<(R^*)-1-tert-butyldimethylsilyloxyethyl>-4-chloroacetoxythio-1-(p-methoxybenzyloxycarbonyl)triphenylphosphoranylidenemethyl-2-azetidinone 
• 92812-19-6 {(3S,4R)-3-((R)-1-Hydroxy-ethyl)-2-oxo-4-[2-([1,3,4]thiadiazol-2-ylsulfanyl)-acetylsulfanyl]-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 
• 92771-94-3 {(2R,3S)-3-((R)-1-Hydroxy-ethyl)-2-[2-(1-methyl-1H-tetrazol-5-ylsulfanyl)-acetylsulfanyl]-4-oxo-azetidin-1-yl}-(triphenyl-λ⁵-phosphanylidene)-acetic acid 4-methoxy-benzyl ester 

Relevant articles and documents

Alkylphosphonous acid diesters, novel reagents for the oxalimide cyclization to penems

Alkylphosphonous acid diesters MeP(OR)2 3a-b were shown to be highly effective and mild reducing reagents in the oxalimide cyclization of azetidinone-1-oxalyl-4-di or tri-thiocarbonates or 4-thioesters 1a-t forming penems 2a-t at lower temperat

AN EFFICIENT SYNTHESIS OF 2-SUBSTITUTED-THIO-6-HYDROXYETHYL-PENEM-3-CARBOXYLIC ACIDS VIA 2-THIOXOPENAMS

Allyl and p-nitrobenzyl (5R,6S)-6-((R)-1-(t-butyldimethylsilyloxy)ethyl)-2-thioxopenam-3-carboxylates (19) were synthesized by base mediated cyclization of the corresponding 1-carboxylmethyl-4-phenoxy(thiocarbonyl)thio-2-azetidinones (16).The thioxopenams underwent alkylation and Michael reactions to produce 2-alkylthio- and 2-alkenylthio-penem derivatives 20 and 21.