88036-17-3Relevant articles and documents
Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: Synthesis and biological activity
Almquist,Olsen,Uyeno,Toll
, p. 115 - 120 (2007/10/02)
A peptide analogue of Leu-enkephalin was synthesized in which the amide linkages between Tyr-Gly and Gly-Gly were replaced by ketomethylene groups. The resulting analogue, x, had 1/4000th and 1/2400th the opiate receptor binding activity of Leu-enkephalin