88039-52-5

Usage

General Description

2-Propenoic acid, 2-(bromomethyl)-3-(4-nitrophenyl)-, ethyl ester, (Z)-, commonly known as bromomethyl nitrophenyl acrylate, is a chemical compound with the molecular formula C12H10BrNO4. It is a yellow solid widely used in the production of photopolymer resins and as a monomer in the synthesis of organic compounds. 2-Propenoic acid, 2-(bromomethyl)-3-(4-nitrophenyl)-, ethyl ester, (Z)- is a versatile building block for the development of materials for various industrial applications, including adhesives, coatings, and photolithography. Additionally, it is used in the manufacturing of dental materials and as a research chemical in chemical synthesis and material science. The (Z)- configuration of the compound refers to the arrangement of the functional groups around the double bond in the molecule.

Upstream product

• 88039-47-8 ethyl 2-(4-nitrohydroxybenzyl)acrylate 
• 140-88-5 ethyl acrylate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 88039-76-3 2-Acetyl-2-methyl-4-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-pentanedioic acid diethyl ester 
• 88039-80-9 2-Acetyl-2-methyl-4-methylene-3-(4-nitro-phenyl)-pentanedioic acid diethyl ester 
• 88039-69-4 2-Acetyl-4-methylene-3-(4-nitro-phenyl)-pentanedioic acid diethyl ester 
• 88039-61-6 2-Acetyl-4-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-pentanedioic acid diethyl ester 
• 950994-14-6 ethyl 2-((4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenoxy)(4-nitrophenyl)methyl)acrylate 
• 1219792-01-4 ethyl 2-((diethoxyphosphoryl)(4-nitrophenyl)methyl)acrylate 
• 1527470-67-2 (Z)-ethyl 2-((4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)methyl)-3-(4-nitrophenyl)acrylate 
• 847653-83-2 ethyl 2-methylene-3-(4-nitrophenyl)pentanoate 

Relevant academic research and scientific papers

Synthesis of 1-benzhydryl piperazine derivatives and evaluation of their ACE inhibition and antimicrobial activities

This study presents the synthesis of 14 new 1,4-disubstituted piperazine derivatives from allyl bromides of Baylis-Hillman adduct and 4,4-disubstituted benzhydryl piperazines. All the synthesized compounds were further screened for in vitro ACE inhibitor and antimicrobial activities. Among the synthesized piperazine derivatives, compound 12h showed moderate ACE inhibitor activity as compared to the standard, angiotensin-converting enzyme inhibitor (Sigma). The kinetic data (K m, K i and V max values) of enzyme inhibition for compound 12h and ACE inhibitor standard were also determined. Similarly, all compounds were screened against different bacterial strains. Compounds 12a, 12b, 12d, 12h and 12i showed excellent to moderate activity against various tested bacterial strains. Compounds 12b and 12i showed broad spectrum of antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, S. aureus MLS 16, Escherichia coli, Bacillus subtilis and Klebsiella planticola, while compounds 12a, 12d and 12i showed promising activity against P. aeruginosa (MIC value of 8.96 μM), S. aureus (MIC value of 42.2 μM) and S. aureus MLS 16 (MIC value of 81.3 μM), respectively. The remaining compounds showed activity at a concentration of >491 μM.

Synthesis and bioactivity of novel (3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl containing acrylate and acrylonitrile derivatives

Fifteen novel (3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl containing Baylis-Hillman adduct derivatives were designed and synthesized. Evaluation of their biological activities showed that methyl 2-((3-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)p

Expedient synthesis of β,β-disubstituted α- methylenepropionates

Baylis-Hillman alcohols are excellent sources of the allylic halides ArCHCH(CH2X)(CO2R) (X=Br, Cl; R1=Me, Et, But). The Z double bond isomers are attained in high isomeric purity (>14:1, Z/E). The halides are ch

Asymmetric chemo- and regiospecific addition of organozinc reagents to Baylis-Hillman derived allylic electrophiles

The copper-catalysed S(N)2' addition of ZnR2 to allylic (Z)-ArCH=C(CH2X)(CO2Et) (X = Br, Cl, OSO2Me) fashions only ArCH(R)C(=CH2)(CO2Et); use of a chiral ligand gives up to 64% ee for this

Necic Acid Synthons. Part 2. Regioselectivity in the Reactions of (Z)-2-Bromomethyl-2-alkenoate Esters with Selected Carbon Nucleophiles

The preparation of selected (Z)-2-bromomethyl-2-alkenoate esters and their subsequent reaction with acetoacetic ester-derived nucleophiles is described.Both the substrate structure and the solvent system have significant effects on the regioselectivity of these nucleophilic displacements.