88052-01-1Relevant academic research and scientific papers
Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety
Foroumadi, Alireza,Ghodsi, Shahram,Emami, Saeed,Najjari, Somayyeh,Samadi, Nasrin,Faramarzi, Mohammad Ali,Beikmohammadi, Leila,Shirazi, Farshad H.,Shafiee, Abbas
, p. 3499 - 3503 (2007/10/03)
N-(Phenethyl)piperazinyl quinolone derivatives that bear a methoxyimino-substituent have been synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. In addition, to define structure-activity relationsh
The first catalytic inverse-electron demand hetero-Diels-Alder reaction of nitroso alkenes using pyrrolidine as an organocatalyst
Wabnitz, Tobias C.,Saaby, Steen,Jorgensen, Karl Anker
, p. 828 - 834 (2007/10/03)
The first catalytic inverse-electron demand hetero-Diels-Alder reaction of nitroso alkenes has been developed. Nitroso alkenes were generated in situ from α-halooximes and underwent [4 + 2]-cycloadditions with enamines as dienophiles formed from aldehydes and pyrrolidine (10 mol%) as an organocatalyst, The presence of a suitable heterogeneous buffer system was found to be essential and best results were obtained with sodium acetate trihydrate. The resulting 5,6-dihydro-4H-oxazines were obtained in moderate to good yields under mild reaction conditions. A catalytic cycle has been proposed and evidence for the cycloaddition mechanism has been obtained. Moderate asymmetric induction (42% ee) was observed when a chiral secondary amine was used.
Fungicidally active novel substituted azolylethyl oximinoalkyl ethers
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, (2008/06/13)
Fungicidally active novel substituted azolylethyl oximinoalkyl ethers of the formula STR1 in which A is a nitrogen atom or the CH group, R1 is optionally substituted phenyl, R2, R3 and R4 each independently is h
