88058-70-2Relevant academic research and scientific papers
Practical Enantioselective Synthesis of a Homotyrosine Derivative and (R,R)-4-Propyl-9-hydroxynaphthoxazine, a Potent Dopamine Agonist
Melillo, David G.,Larsen, Robert D.,Mathre, David J.,Shukis, William F.,Wood, Alfred W.,Colleluori, Joseph R.
, p. 5143 - 5150 (2007/10/02)
Two enantioselective routes were developed to prepare chiral amino acid derivative 4.The key step in the first route was catalytic hydrogenation of acrylate derivative 3 using chiral rhodium catalysts.In the second route the key step was acylation of 2-ch
Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists
Jones,Anderson,Baldwin,Clineschmidt,McClure,Lundell,Randall,Martin,Williams,Hirshfield
, p. 1607 - 1613 (2007/10/02)
A series of tricyclic oxazines, namely, the 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, have been synthesized and assayed for dopamine agonist activity. One of the members of this series was found to be a remarkably potent agonist in vivo when tested in
Hexahydronaphth[1,2-b]-1,4-oxazines
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, (2008/06/13)
Hexahydronaphth[1,2-b]-1,4-oxazines have dopaminergic activity and display α 2 -adrenergic receptor antagonism. They are useful in the treatment of parkinsonism, depression and hypertension. An important method of preparation is by ring closure of the app
