88069-49-2 Usage
Uses
Used in Cardiology:
Pilsicainide hydrochloride is used as a sodium channel blocker for the treatment of premature ventricular contraction. It is effective in managing arrhythmias and has been studied for its effects on electrophysiological parameters in guinea pig pulmonary vein preparation, its effects on Ca2+ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes, and its electrophysiological effects on the guinea pig atrium.
Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.
Check Digit Verification of cas no
The CAS Registry Mumber 88069-49-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,0,6 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 88069-49:
(7*8)+(6*8)+(5*0)+(4*6)+(3*9)+(2*4)+(1*9)=172
172 % 10 = 2
So 88069-49-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O.ClH.H2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H;1H2
88069-49-2Relevant academic research and scientific papers
Method of Manufacturing Pyrrolizidine Compound And Method of Manufacturing Pyrrolizidine Hydrochloride Hemihydrate
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Paragraph 0059-0102, (2021/07/13)
The present invention relates to a method for manufacturing a pyrrolizidine compound and a method for manufacturing pyrrolizidine hydrochloride hemihydrate. According to the present invention, by including the reaction using phosphoryl chloride (POCl_3) and pyridine, and also aniline intermediates, it is possible to provide effects of lowering the manufacturing cost of the pyrrolizidine compound and pyrrolizidine hydrochloride hemihydrate, solving the manufacturing environmental problem, and at the same time, increasing a manufacturing yield.
Novel method for preparing pilsicainide hydrochloride
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, (2021/01/12)
The invention discloses a preparation method of pilsicainide hydrochloride. The preparation method comprises the following steps of: by taking 2, 6-dimethylaniline as a raw material, carrying out amidation reaction on the 2, 6-dimethylaniline and a compou
