15960-82-4

Upstream product

• 87-62-7 2,6-dimethylaniline 
• 105-53-3 diethyl malonate 
• 1071-46-1 hydrogen ethyl malonate 
• 201230-82-2 carbon monoxide 
• 623-48-3 ethyl iodoacetae 
• 119072-54-7 2,6-dimethylphenyl isonitrile 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 100616-40-8 N-(2,6-dimethyl-phenyl)-2-hydroxyimino-malonamic acid ethyl ester 
• 15961-02-1 2-Bromo-2-carbamoylaceto-2',6'-xylidid 
• 102881-97-0 2-amino-N-(2,6-dimethyl-phenyl)-malonamic acid ethyl ester 
• 15883-20-2 2',6'-pipecoloxylidide 
• 15960-97-1 2-Bromo-2-ethoxycarbonylaceto-2',6'-xylidid 
• 15961-01-0 2-Carbamoylaceto-2',6'-xylidid 

Relevant academic research and scientific papers

Novel method for preparing pilsicainide hydrochloride

The invention discloses a preparation method of pilsicainide hydrochloride. The preparation method comprises the following steps of: by taking 2, 6-dimethylaniline as a raw material, carrying out amidation reaction on the 2, 6-dimethylaniline and a compou

Visible-Light Photocatalytic Functionalization of Isocyanides for the Synthesis of Secondary Amides and Ketene Aminals

A new visible light-induced photocatalytic protocol enabling the formation of secondary amides from electron-poor organic bromides and isocyanides was developed. In addition, the in situ interception of ketenimine intermediates with nitrogen nucleophiles such as amines, hydrazines, and TMSN3 afforded, in a one-pot two-step procedure, valuable scaffolds such as ketene aminals, pyrazolones, and tetrazoles. Mechanistic evidence confirmed a radical pathway where isocyanides acted as radical geminal acceptors generating key imidoyl radical species.

Transformations of Isonitriles with Bromoalkanes Using Photoredox Gold Catalysis

Isonitriles have excellent electronic compatibility to react with free radicals. Recently, photoredox catalysis has emerged as a powerful tool for the construction of C-C bonds with few protocols for alkylative heterocycle synthesis through isonitrile addition. Herein, we describe the photocatalytic generation of alkyl radicals from unactivated bromoalkanes as part of an efficient cross-coupling strategy for the diversification of isonitriles using a dimeric gold(I) photoredox catalyst, [Au2(dppm)2]Cl2.

Synthesis of carbamoylacetates from α-iodoacetate, CO, and amines under Pd/light combined conditions

We developed a novel synthetic method of carbamoylacetates from -iodoacetate, carbon monoxide, and amines under photoirradiation conditions in the presence of a Pd catalyst. This reaction likely proceeds via interplay of radical and organopalladium species. Georg Thieme Verlag Stuttgart · New York.