880769-26-6Relevant articles and documents
METHOD FOR PRODUCING MONTELUKAST ALKYL ESTER
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, (2018/02/28)
PROBLEM TO BE SOLVED: To provide a method for efficiently producing a high purity 1-(((1(R)-(3-(2-(7-chloro-2-quinonyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid alkyl ester having a reduced content of a specific impurity. SOLUTION: A specific amount of a weakly basic nitrogen-containing organic compound is made to exist in a reaction system in a reaction between 2(2-(3(S)-(3-(2-(7-chloro-2-quinonyl)ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl)-2-propanol and 1-mercaptomethylcyclopropane acetic acid alkyl ester in the presence of a strong base. COPYRIGHT: (C)2015,JPO&INPIT
PURIFICATION OF MONTELUKAST
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Page/Page column 18, (2010/11/25)
The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast of formula I, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.