918972-53-9

Basic information

• Product Name: montelukast isopropylamine salt
• Synonyms: montelukast isopropylamine salt
• CAS NO: 918972-53-9
• Molecular Weight: 645.306
• Mol File: 918972-53-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: montelukast isopropylamine salt(CAS DataBase Reference)
• NIST Chemistry Reference: montelukast isopropylamine salt(918972-53-9)
• EPA Substance Registry System: montelukast isopropylamine salt(918972-53-9)

Safety Data

• Hazardous Substances Data: 918972-53-9(Hazardous Substances Data)

Upstream product

• 75-31-0 isopropylamine 
• 151767-02-1 Montelukast sodium 
• 880769-28-8 2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 

Downstream Products

• 880769-26-6 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt 
• 945934-73-6 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt 
• 151767-02-1 Montelukast sodium 
• 158966-92-8 montelukast 

Relevant articles and documents

METHOD FOR ISOLATION AND PURIFICATION OF MONTELUKAST

A method of isolation of Montelukast of formula I from reaction mixtures, comprising conversion of the crude sub-stance to well-crystallizing salts with primary amines in the environment of at least one organic solvent and acetonitrile, followed by re-crystallization of these salts with simultaneous removal of chemical impurities and use of the chemically pure salts of Montelukast with primary amines for direct transformation to the pharmaceutically useful amorphous form of Montelukast sodium of formula II.

PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS SALTS THEREOF

The present invention relates to the alkyl amine salts of Montelukast and methods for their preparation and conversion of Montelukast amine salts to Montelukast or Montelukast alkali/alkaline salt.