88099-67-6

Basic information

• Product Name: N,N-DIBENZYL-L-SERINE METHYL ESTER
• Synonyms: (S)-2-DIBENZYLAMINO-3-HYDROXYPROPIONIC ACID METHYL ESTER;N,N-DIBENZYL-L-SERINE METHYL ESTER;N,N-Dibenzyl-L-serine methyl ester 97%
• CAS NO: 88099-67-6
• Molecular Formula: C₁₈H₂₁NO₃
• Molecular Weight: 299.36
• Mol File: 88099-67-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 449.5oC at 760 mmHg
• Flash Point: 225.6oC
• Appearance: /
• Density: 1.201 g/mL at 25 °C(lit.)
• Vapor Pressure: 7.27E-09mmHg at 25°C
• Refractive Index: n20/D 1.5550(lit.)
• CAS DataBase Reference: N,N-DIBENZYL-L-SERINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIBENZYL-L-SERINE METHYL ESTER(88099-67-6)
• EPA Substance Registry System: N,N-DIBENZYL-L-SERINE METHYL ESTER(88099-67-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 88099-67-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H21NO3/c1-22-18(21)17(14-20)19(12-15-8-4-2-5-9-15)13-16-10-6-3-7-11-16/h2-11,17,20H,12-14H2,1H3/t17-/m0/s1

Upstream product

• 2788-84-3 (S)-serine methyl ester 
• 100-39-0 benzyl bromide 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 186581-53-3 diazomethane 
• 93527-55-0 (S)-2-(dibenzylamino)-3-hydroxypropanoic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 1032661-60-1 9-N-[methyl-N-(dibenzyl)-L-serinate-3-yl]-7,8-di-O-benzoyl-4,10-dioxa-3-thia-2-azabicyclo[4.2.2]decane-3,3-dioxide 
• 882872-71-1 C₁₈H₂₀FNO₂ 
• 88099-68-7 methyl (2R)-3-N,N-dibenzylamino-2-fluoropropanoate 
• 911404-06-3 C₁₉H₂₃NO₅S 
• 180067-83-8 (2S,3S)-2-Dibenzylamino-1-(2-methoxy-ethoxymethoxy)-pentan-3-ol 
• 1026585-90-9 (R)-2-Dibenzylamino-3-(2-methoxy-ethoxymethoxy)-propan-1-ol 
• 180067-79-2 (S)-2-Dibenzylamino-3-(2-methoxy-ethoxymethoxy)-propionaldehyde 
• 208184-52-5 Dibenzyl-[(1S,2R)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine 
• 208184-48-9 Dibenzyl-[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(2-methoxy-ethoxymethoxy)-butyl]-amine 

Relevant articles and documents

NEW MACROCYCLIC LRRK2 KINASE INHIBITORS

Compounds of formula (I): wherein R, X1, X2, X3, Z1, Z2, Z3, A and Ra are as defined in the description. Medicaments.

HETEROARYL SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE MODULATORS

Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, including IRAK-4 inhibition.

Synthesis and pharmacological evaluation of novel γ-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors

We have previously demonstrated that the prototypical GABAB receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the most important mechanism for gastroesophageal reflux. Thus, GABAB agonists could be exploited for the treatment of gastroesophageal reflux disease. However, baclofen, which is used as an antispastic agent, and other previously known GABAB agonists can produce CNS side effects such as sedation, dizziness, nausea, and vomiting at higher doses. We now report the discovery of atypical GABAB agonists devoid of classical GABAB agonist related CNS side effects at therapeutic doses and the optimization of this type of compound for inhibition of TLESRs, which has resulted in a candidate drug (R)-7 (AZD3355) that is presently being evaluated in man.