881-05-0

Basic information

• Product Name: 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl-
• Synonyms: 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl-
• CAS NO: 881-05-0
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18272
• Mol File: 881-05-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 118-120 °C
• Boiling Point: 289.9±23.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• PKA: -0.11±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl-(881-05-0)
• EPA Substance Registry System: 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl-(881-05-0)

Safety Data

• Hazardous Substances Data: 881-05-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl- is a chemical compound with the formula C10H8N2O2. It is a derivative of pyrazole, with a methyl group and a phenyl group attached to the pyrazole ring. 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl- is commonly used in organic synthesis and medicinal chemistry as a key intermediate in the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anti-inflammatory and analgesic properties. Additionally, 1H-Pyrazole-4,5-dione,3-Methyl-1-phenyl- has been investigated for its potential use in photochromic materials and as a building block for the synthesis of new functional materials.

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 61799-28-8 4-<<4-(dimethylamino)phenyl>-imino>-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 89-25-8 edaravone 
• 4595-01-1 4-(4-diethylaminophenylimino)-5-methyl-2-phenyl-3,4-dihydro-2H-pyrazol-3-one 
• 99694-71-0 4-aminoantipyrine 
• 7705-08-0 iron(III) chloride 
• 7664-93-9 sulfuric acid 
• 1055-31-8 1,5,5'-trimethyl-2,2'-diphenyl-1,2,2',4'-tetrahydro-4,4'-azanylylidene-bis-pyrazol-3-one 
• 60-29-7 diethyl ether 
• 1456-89-9 1-Phenyl-3-methyl-4-(4-dimethylaminophenylimino)-pyrazolin-5-on 
• 4593-76-4 1-phenyl-3-methyl-4-benzhydryl-2-pyrazolin-5-one 
• 1242853-39-9 3-methyl-1-phenyl-4-(phenyldiazenyl)-1H-pyrazol-5-ol 
• 117985-05-4 (E)-5-methyl-2-phenyl-4-(phenylimino)-2,4-dihydro-3H-pyrazol-3-one 

Downstream Products

• 62094-95-5 rubazonic acid 
• 75380-48-2 2,3-bis(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)quinoxaline 
• 50818-04-7 4-((4-chlorophenyl)imino)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 27934-17-4 4-((4-methoxyphenyl)imino)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 

Relevant articles and documents

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole-4,5-Diones and Indoline-2,3-Diones

The catalytic enantioselective diorganozinc additions to cyclic diketones including pyrazolin-4,5-diones and isatins have been developed. In the presence of morpholine-containing chiral amino alcohol ligand, the corresponding chiral cyclic tertiary alcohols were produced in good to excellent yields (up to 97 %) and enantioselectivities (up to 95 % ee). The notable feature of this protocol includes its mild reaction conditions, Lewis acid additives free and broad functional group tolerance.

Iodine-Catalyzed Construction of Dihydrooxepines via 3-Methyl-5-Pyrazolones C?H Oxidation/Functionalization of Quinolines Cascade

An efficient iodine-catalyzed [3+3+1] annulation for the construction of dihydrooxepine scaffolds with quinoline units was developed. This strategy involves a seven-membered dihydrooxepine with a broad substrate scope through a formal three-component tandem reaction. Further derivation of the target product produced a trioxabicycle scaffold, which formed the basic core of natural products and pharmaceutical molecules.

Asymmetric Organocatalytic Friedel-Crafts Hydroxyalkylation of Indoles Using Electrophilic Pyrazole-4,5-diones

The electrophilic reactivity of a series of novel pyrazole-4,5-dione derivatives in the organocatalytic Friedel-Crafts reaction with various substituted indoles has been tested. The disclosed procedure catalyzed by a cinchona alkaloid derivative allows the conjugation of two very important aza-heterocyclic scaffolds to generate a new class of indolylpyrazolones bearing a tetrasubstituted stereocenter in excellent yields (up to 99%) and with enantioselectivities of up to 94:6 er.