1080-89-3

Usage

Uses

Used in Medicinal Chemistry:
5-METHYL-2-PHENYL-2H-PYRAZOLE-3,4-DIONE 4-OXIME is used as a potential therapeutic agent for its antioxidant and antitumor properties, which may contribute to the development of new drugs for various diseases.
Used in Coordination Chemistry:
In the field of coordination chemistry, 5-METHYL-2-PHENYL-2H-PYRAZOLE-3,4-DIONE 4-OXIME is used as a ligand to form coordination complexes with metal ions, which can be applied in various areas such as catalysis, materials science, and analytical chemistry.

Upstream product

• 881-05-0 3-Methyl-1-phenyl-2-pyrazoline-4,5-dione 
• 384814-78-2 malonic acid bis-(2-ethoxycarbonyl-2-hydroxyimino-1-methyl-ethylidenehydrazide) 
• 64-17-5 ethanol 
• 89-25-8 edaravone 
• 6028-98-4 2-hydroxyimino-3-phenylhydrazono-butyric acid ethyl ester 
• 124325-20-8 1-Phenyl-3-methyl-4-nitroso-5-ethanesulfonamidopyrazole 
• 52943-85-8 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 
• 7647-01-0 hydrogenchloride 
• 22123-17-7 4-isopropylidene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 117985-07-6 4-Diethylamino-phenylimino-3-methyl-1-phenyl-2-pyrazolin-5-on 
• 100-63-0 phenylhydrazine 
• 1456-89-9 1-Phenyl-3-methyl-4-(4-dimethylaminophenylimino)-pyrazolin-5-on 

Downstream Products

• 292630-65-0 6-imino-3-methyl-1-phenyl-1,6-dihydro-pyrazolo[3,4-b][1,4]oxazine-5-carbonitrile 
• 481705-22-0 5-[2-(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylimino)-acetylamino]-4-oxo-3-phenyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester 
• 54205-17-3 Ni(C₁₀H₈N₃O₂)2(H₂O)2 
• 79666-42-5 Fe(4-oximinato-1-phenyl-3-methyl-2-pyrazolin-5-one)2(H₂O)2 
• 82428-89-5 (C₃N₂(NO)(CH₃)(C₆H₅)(O))2(3-picoline)2Zn(II) 
• 82428-81-7 (C₃N₂(NO)(CH₃)(C₆H₅)(O))2(3-picoline)2Ni(II) 
• 82428-85-1 (C₃N₂(NO)(CH₃)(C₆H₅)(O))2(pyridine)2Zn(II) 
• 82428-78-2 (C₃N₂(NO)(CH₃)(C₆H₅)(O))2(pyridine)2Ni(II) 

Relevant academic research and scientific papers

Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor

A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and enantioselectivity. A chiral sulfoxide derivative of this dispirocyclic product was identified to be a promising hit of the human carboxylesterase 1 inhibitor, and the significant difference of the activity between two enantiomers emphasized the importance of this asymmetric process.

A New Fused Heterocyclic System: 6H-Pyrazolothiadiazine 2,2-Dioxide

A base-promoted cyclodehydration of 4-nitroso-5-alkylsulfonylamidopyrazoles 3 afforded 6H-pyrazolothiadiazine 2,2-dioxide (4).The structure of 4 was confirmed through X-ray analysis.