881015-10-7Relevant articles and documents
Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction
Albaneze-Walker,Rossen,Reamer,Volante,Reider
, p. 4917 - 4920 (1999)
Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.