881033-63-2

Upstream product

• 881033-97-2 methyl 3-(hydroxy)thieno[3,2-b][1]benzothiophene-2-carboxylic acid methyl ester 
• 21211-07-4 3-chlorobenzo[b]thiophene-2-carboxylic acid methyl ester 
• 881033-98-3 methyl 3-(tert-butoxycarbonylmethoxy)thieno[3,2-b][1]benzothiophene-2-carboxylate 

Relevant academic research and scientific papers

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallo

PTP1b inhibitors

This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).