88109-49-3Relevant academic research and scientific papers
Studies related to Cephalosporins. Part 1. Solvolytic Reactions of 3-Bromomethylcephems with Alcohols and Phenols
Animati, Fabio,Botta, Maurizio,De Angelis, Francesco,Dorigo, Andrea,Grgurina, Ingeborg,Nicoletti, Rosario
, p. 2281 - 2286 (2007/10/02)
3-Bromomethyl-3-cephems are solvolyzed by alcohols, similarly to the Δ2-isomers.The yields are fairly good and this reaction represents a straightforward route to obtain 3-alkoxymethyl-3-cephems.Both 3-bromomethyl-2-cephems and 3-bromomethyl-3-isomers react with a variety of phenols under solvolytic conditions, giving only C-substitution products.This reaction represents the sole example of C-alkylation of phenols by an allylic bromide under such mild conditions.
