881097-91-2Relevant academic research and scientific papers
Lessons in Strain and Stability: Enantioselective Synthesis of (+)-[5]-Ladderanoic Acid
Hancock, Erin N.,Kuker, Erin L.,Tantillo, Dean J.,Brown, M. Kevin
, p. 436 - 441 (2020)
The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)-[5]-ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefination sequence.
