881205-08-9 Usage
Uses
Used in Pharmaceutical Industry:
1-(4-chloropyridin-2-yl)-N-MethylMethanaMine is used as a chemical intermediate for the preparation of indole derivatives that act as inhibitors of the interaction between MDM2 and p53 proteins. This interaction plays a crucial role in the regulation of the cell cycle and apoptosis, and its inhibition can have potential therapeutic benefits in the treatment of various cancers.
In the synthesis of these indole derivatives, 1-(4-chloropyridin-2-yl)-N-MethylMethanaMine serves as a building block, providing the necessary structural elements and functional groups for the formation of the desired compounds. Its reactivity and compatibility with other chemical moieties make it a valuable component in the development of novel therapeutic agents targeting the MDM2-p53 interaction.
Check Digit Verification of cas no
The CAS Registry Mumber 881205-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,1,2,0 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 881205-08:
(8*8)+(7*8)+(6*1)+(5*2)+(4*0)+(3*5)+(2*0)+(1*8)=159
159 % 10 = 9
So 881205-08-9 is a valid CAS Registry Number.
881205-08-9Relevant articles and documents
Use of Metal Complex Compounds as Oxidation Catalysts
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, (2009/03/07)
The present invention relates to the use, as oxidation catalysts, of metal complex compounds having tetradentate ligands of formula (2) wherein all substitutents have the meanings as defined in Claim 1. The present invention relates also to formulations comprising such metal complex compounds, to novel metal complex compounds and to novel ligands.
INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53
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Page/Page column 58, (2010/10/20)
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z have defined meanings.
ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS
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Page 86, (2010/02/10)
Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', R
