88121-96-4Relevant academic research and scientific papers
Effect of Piperidine on Benzylaspartyl Peptides in Solution and in the Solid Phase
Schoen, Istvan,Colombo, Roberto,Csehi, Attila
, p. 505 - 507 (1983)
Basic conditions (e.g. piperidinolysis), used for the removal of the Nα-9-fluorenylmethyloxycarbonyl group, lead to significant cleavage of side-chain benzyl esters of peptides containing benzylaspartyl residues both in solution and solid-phase syntheses, the intermediate imide derivative is slowly transformed to a mixture of piperidides.
