
Journal of the Chemical Society. Chemical communications p. 505 - 507 (1983)
Update date:2022-08-03
Topics:
Schoen, Istvan
Colombo, Roberto
Csehi, Attila
Basic conditions (e.g. piperidinolysis), used for the removal of the Nα-9-fluorenylmethyloxycarbonyl group, lead to significant cleavage of side-chain benzyl esters of peptides containing benzylaspartyl residues both in solution and solid-phase syntheses, the intermediate imide derivative is slowly transformed to a mixture of piperidides.
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