88124-26-9 Usage
Originator
Adosopine ,Menarini Group
Manufacturing Process
2 ml of acetic anhydride are added to 2.5 g of 10-amino-5,6-dihydro-11Hdibenzo[
b,e]azepine-6,11-dione (prepared from 1-aminoanthraquinone in
accordance with Caronna and Palazzo-Gaz. Chim. It. 83, 533, 1953) in 50 ml
of dioxane. After maintaining for 2 h under reflux, the mixture is evaporated
almost to dryness under reduced pressure, the residue is then poured into
water, filtered and dried to give 2.0 g of crude product.
The 2.0 g of previously obtained crude product is suspended in 20 ml of N,Ndimethylformamide,
and 710.0 mg of sodium methylate in 10 ml of methanol
are added. After maintaining for 30 min at room temperature, 2.5 ml of
methyl iodide are added, and mixture is allowed to stand for 24 h after which
the mixture is poured into water, the product filtered off, dried and crystallized
from ethanol, to give 5-methyl-10-acetamino-5,6-dihydro-11H-dibenzo[b,e]
azepine-6,11-dione, melting point 199°-201°C.
Therapeutic Function
Urinary incontinence agent
Check Digit Verification of cas no
The CAS Registry Mumber 88124-26-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,1,2 and 4 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 88124-26:
(7*8)+(6*8)+(5*1)+(4*2)+(3*4)+(2*2)+(1*6)=139
139 % 10 = 9
So 88124-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H14N2O3/c1-10(20)18-13-8-5-7-12-15(13)16(21)11-6-3-4-9-14(11)19(2)17(12)22/h3-9H,1-2H3,(H,18,20)
88124-26-9Relevant articles and documents
Synthesis, characterization, and analytical studies of adosupine, a potential new drug for urinary incontinence
Perico,Triolo,Viti,Mannucci,Caviglioli,Cocchini,Pestellini,Paoli,Dapporto
, p. 137 - 142 (1994)
The synthesis and the spectroscopic characterization of a new potential drug for urinary incontinence, adosupine, is described. Adosupine and its potential synthesis impurities were analyzed by a new HPLC method that was developed with a C18 reversed-phase column. The analysis was made under isocratic conditions, with a mobile phase of acetonitrile:water (15:85, v/v). Resolution of all synthesis impurities was allowed. The method was also applied to stability studies of adosupine in solid state and in solution under different conditions. With the conditions used, only one degradation product was shown by HPLC analysis; it was isolated, characterized, and identified as the hydrolysis product of the lactam ring present in the adosupine structure.
