88126-44-7Relevant academic research and scientific papers
Synthesis and antiprotozoal activity of 4-arylcoumarins
Pierson, Jean-Thomas,Dumètre, Aurélien,Hutter, Sébastien,Delmas, Florence,Laget, Michèle,Finet, Jean-Pierre,Azas, Nadine,Combes, Sébastien
experimental part, p. 864 - 869 (2010/04/26)
A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation
Synthesis of 4-arylcoumarins via Cu-catalyzed hydroarylation with arylboronic acids
Yamamoto, Yoshihiko,Kirai, Naohiro
supporting information; experimental part, p. 5513 - 5516 (2009/05/27)
(Chemical Equation Presented) In the presence of 2-4 mol % of CuOAc, methyl phenylpropiolates having a MOM-protected hydroxy group at the ortho position underwent hydroarylation with various arylboronic acids in MeOH at ambient temperature, resulting in the formation of 4-arylcoumarins in high yields after the acidic workup. This method was effectively used for the synthesis of biologically active natural and artificial compounds.
Synthesis and Biological Evaluation of 4-Arylcoumarin Analogues of Combretastatins
Bailly, Christian,Bal, Christine,Barbier, Pascale,Combes, Sébastien,Finet, Jean-Pierre,Hildebrand, Marie-Paule,Peyrot, Vincent,Wattez, Nicole
, p. 5437 - 5444 (2007/10/03)
A series of A-ring polymethoxylated neoflavonoids was prepared by ligand coupling reactions involving either Suzuki or Stille reactions. Cytotoxicity studies indicated a potent activity against a CEM leukemia cell line for the compounds presenting a subst
Synthesis of C-ring hydroxylated neoflavonoids by ligand coupling reactions
Donnelly, Dervilla M.X.,Finet, Jean-Pierre,Guiry, Patrick J.,Rea, Martin D.
, p. 2719 - 2730 (2007/10/03)
Reaction of 4-trifluoromethanesulfonyloxycoumarin derivatives with benzyloxyphenylboronic acid derivatives under modified Suzuki reaction conditions afforded the corresponding neoflavones. Selective debenzylation took place in high yields when the palladi
Synthesis of 4-phenylcoumarins
Bose,Banerji
, p. 422 - 424 (2007/10/02)
Six new 4-phenylcoumarins, viz. 7-hydroxy-4,'5-dimethoxy-(5a)-, 5-hydroxy-4',7-dimethoxy-(5b)-, 7,4'-dihydroxy-5-methoxy-(6a)-, 4',5-dihydroxy-7-methoxy-(6b)-, 4'-benzyloxy-7-hydroxy-5-methoxy-(7a)- and 4'-benzyloxy-5-hydroxy-7-methoxy-(7b)-4-phenylcoumar
Synthesis of New Naturally Occuring 4-Phenyl-2H-1-benzopyran-2-ones
Parmar, Virinder S.,Jain, Rajni,Singh, Suddham
, p. 2277 - 2280 (2007/10/02)
5,7-Dimethoxy-4-(4-hydroxyphenyl)-2H-1-benzopyran-2-one and 5,7-dimethoxy-4-(4-methoxyphenyl)-2H-1-benzopyran-2-one, two new neoflavonoids occuring in Courtarea hexandra have been synthesized via Pechmann condensation.Attempts made to synthesize another 4-arylcoumarin, 5-hydroxy-7-methoxy-4-(2,5-dihydroxyphenyl)-2H-1-benzopyran-2-one, constituent of the same plant, led to the formation of the hitherto unknown 2-ethoxy-6-hydroxy-4H-1-benzopyran-4-one.
SYNTHESIS OF 4-ARYLCOUMARINS FROM COUTAREA HEXANDRA
Monache, Giuliano Delle,Botta, Bruno,Monache, Franco Delle,Botta, Maurizio
, p. 1355 - 1358 (2007/10/02)
Key Word Index - Coutarea hexandra; Rubiaceae; neoflavonoids; 4-arylcoumarins; synthesis. - The structures assigned to the 5,7-dimethoxy-4-arylcoumarins isolated from Coutarea hexandra have been confirmed by synthesis, via Pechmann condensation of phlorog
