88134-01-4Relevant academic research and scientific papers
Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABAA receptors
Fuchs, Alexander,Baur, Roland,Schoeder, Clara,Sigel, Erwin,Müller, Christa E.
, p. 6908 - 6917 (2014)
Biphenylic compounds related to the natural products magnolol and 4′-O-methylhonokiol were synthesized, evaluated and optimized as positive allosteric modulators (PAMs) of GABAA receptors. The most efficacious compounds were the magnolol analog 5-ethyl-5′-hexylbiphenyl-2,2′-diol (45) and the honokiol analogs 4′-methoxy-5-propylbiphenyl-2-ol (61), 5-butyl-4′-methoxybiphenyl-2-ol (62) and 5-hexyl-4′-methoxybiphenyl-2-ol (64), which showed a most powerful potentiation of GABA-induced currents (up to 20-fold at a GABA concentration of 3 μM). They were found not to interfere with the allosteric sites occupied by known allosteric modulators, such as benzodiazepines and N-arachidonoylglycerol. These new PAMs will be useful as pharmacological tools and may have therapeutic potential for mono-therapy, or in combination, for example, with GABAA receptor agonists.
Ortho Cyano Substituted Negative Dielectric Anisotropic Liquid Crystals
Hong, X. J.,Ge, M. J.,Zhao, X. M.,Fen, Z. R.,Liu, Z. J.
, p. 81 - 88 (2007/10/02)
A homologous series of 2'-cyano-4'-n-alkylbiphenylcarboxylates and 4-n-alkylcyclohexyl-p-benzoates were synthesized by treating 2'-cyano-4'-n-alkyl substituted phenols with 4-n-alkyl substituted biphenyl carboxylic acids and cyclohexyl benzoic acids.The method of synthesis was discussed.All these compounds were nematogenic in character and their phase transition temperatures were examined.A wide range of mesomorphism was observed in almost all the homologous series.IR, NMR, and dielectric property of these compounds were studied studied.The negative dielectric anisotropic property of these liquid crystalline compounds makes them suitable for application in positive GH display devices.
