88137-16-0

Basic information

• Product Name: 3-{(E)-2-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride
• Synonyms: 3-{(E)-2-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride
• CAS NO: 88137-16-0
• Molecular Weight: 386.878
• Mol File: 88137-16-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{(E)-2-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{(E)-2-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride(88137-16-0)
• EPA Substance Registry System: 3-{(E)-2-[2-(2-Morpholin-4-yl-ethoxy)-phenyl]-vinyl}-benzo[d]isoxazole; hydrochloride(88137-16-0)

Safety Data

• Hazardous Substances Data: 88137-16-0(Hazardous Substances Data)

Upstream product

• 37924-85-9 3-bromomethyl-1,2-benzisoxazole 
• 68997-45-5 2-[2-(4-Morpholinyl)ethoxy]benzaldehyde 
• 88137-14-8 3-(triphenylphosphoniummethyl)-1,2-benzisoxazole bromide 

Relevant articles and documents

Synthesis and spasmolytic activity of 2-substituted-3-(ω-dialkylamino-alkoxyphenyl)acrylonitriles and related compounds

Several analogs of (Z)-2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]-acryloni trile, such as (Z)-2-(1,2-benzisothiazol-3-yl)-, (Z)-2-(1H-indol-3-yl)-, (E)-2-(2-thienyl)- and (E)-2-benzoyl-3-(ω-dialkylaminoalkoxyphenyl)acrylonitriles, were synthesized by means of the Knoevenagel condensation. The descyano analog was prepared by means of the Wittig reaction. Triethylammonium formate reduction of 2-(1,2-benzisoxazol-3-yl)-3-(ω-dialkylaminoalkoxyphenyl)acrylonitriles afforded the dihydro analog. The spasmolytic activities of these analogs were examined. Among these compounds, (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]-acrylonit rile and (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-morpholinoethoxy)phenyl]acrylon itrile showed potent antispasmodic activities in vitro and in vivo (in mice).