88137-32-0

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 20413-06-3 (E)-2-benzoyl-3-(4-methoxyphenyl)acrylonitrile 

Downstream Products

• 100784-42-7 3-carbamoyl-5-cyano-6-hydroxy-4-(p-methoxyphenyl)-6-phenylpiperidin-2-one 
• 75238-83-4 3,5-dicyano-6-hydroxy-4-(p-methoxyphenyl)-6-phenyl-2-piperidone 
• 86625-41-4 2-Methylthio-4-(4-methoxyphenyl)-6-phenyl-3,5-pyridinedicarbonitrile 
• 86625-31-2 1,2-Dihydro-4-(4-methoxyphenyl)-6-phenyl-2-thioxo-3,5-pyridinedicarbonitrile 
• 100784-51-8 3-carbamoyl-5-cyano-4-(p-methoxyphenyl)-6-phenylpyridin-2(1H)-one 
• 100784-46-1 3-carbamoyl-5-cyano-4-(p-methoxyphenyl)-6-phenyl-3,4-dihydropiridin-2(1H)-one 
• 82791-79-5 5-Amino-4-(4-methoxy-phenyl)-2-phenyl-furan-3-carbonitrile 
• 82791-89-7 7-Amino-6-(4-methoxy-phenyl)-1,3-dioxo-4-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 1378998-62-9 C₂₃H₂₃NO₃ 

Relevant academic research and scientific papers

Reduced graphene oxide supported piperazine in aminocatalysis

Reduced graphene oxide (rGO) has been used as a support for piperazine to provide a heterogeneous bifunctional organocatalyst (rGO-NH) that is able to efficiently promote vintage organic transformations such as Knoevenagel, Michael and aldol reactions. The obtained results suggest a significant role of the support in the course of these reactions. This journal is the Partner Organisations 2014.

Microwave synthesis of α-cyano chalcones

A novel methodology for facile production of α-cyano chalcones under microwave irradiation is described. Utilizing a Knoevenagel condensation between benzoylacetonitriles and aromatic aldehydes, substituted chalcones are generated via a 15-min, one-pot synthesis. Diversification of aromatic groups, including electron-withdrawing, electron-donating, and heterocyclic substitutions, has led to the isolation of over twenty colored, solid chalcone products. Furthermore the methodology can be extended to the synthesis of benzylidenemalononitriles as well as methyl and ethyl α-cyano cinnamates.

New routes to the synthesis of pyridazinone, ethoxypyridine, pyrazole and pyrazolo[1,5-a]pyrimidine derivatives incorporating a benzotriazole moiety

A new approach to the synthesis of pyridazinone, ethoxypyridine, pyrazole and 7-aminopyrazolo-[1,5-a]pyrimidine derivatives. The structure of the newly synthesized compounds was elucidated by elemental analyses, ir, 1H nmr spectra and in some cases by 13C nmr investigations.

Hetero-Diels-Alder Reaction of 3-Aryl-2-benzoyl-2-propenenitriles with Enol Ethers. Synthesis of 2-Alkoxy-3,4-dihydro-2H-pyran-5-carbonitriles

The hetero-Diels-Alder reaction of 3-aryl-2-benzoyl-2-propenenitriles 1a-d with enol ethers 2a-c yields cis/trans diastereoisomers of 2-alkoxy-4,6-diaryl-3,4-dihydro-2H-pyran-5-carbonitriles 3 and 4 in 79-98% yield. The similar reaction of 1a-c with cyclic enol ether 5 affords diastereoisomeric cycloadducts 6 and 7 with cis annulated pyran rings. Reaction of 3 with sulfuric acid leads to 2-hydroxy-3,4-dihydro-2H-pyran-5-carbonitriles 8 and 9.

Silica-Gel-Catalysed Knoevenagel Condensation of Peptidyl Cyanomethyl Ketones with Aromatic Aldehydes and Ketones. A Novel Michael Acceptor Functionality for C-Modified Peptides: The Benzylidene and Alkylidene Cyanomethyl Ketone Function

Simple preparation of cyanomethyl ketone derivatives 5a-5b of N-acetylphenylalanine and N-acetylleucylphenylalanine is accomplished by condensation of the corresponding activated carboxylic acids 3a-3b and the carbanion of tert-butyl cyanoacetate to give

Synthesis and spasmolytic activity of 2-substituted-3-(ω-dialkylamino-alkoxyphenyl)acrylonitriles and related compounds

Several analogs of (Z)-2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]-acryloni trile, such as (Z)-2-(1,2-benzisothiazol-3-yl)-, (Z)-2-(1H-indol-3-yl)-, (E)-2-(2-thienyl)- and (E)-2-benzoyl-3-(ω-dialkylaminoalkoxyphenyl)acrylonitriles, were synthesized by means of the Knoevenagel condensation. The descyano analog was prepared by means of the Wittig reaction. Triethylammonium formate reduction of 2-(1,2-benzisoxazol-3-yl)-3-(ω-dialkylaminoalkoxyphenyl)acrylonitriles afforded the dihydro analog. The spasmolytic activities of these analogs were examined. Among these compounds, (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]-acrylonit rile and (Z)-2-(1,2-benzisothiazol-3-yl)-3-[2-(2-morpholinoethoxy)phenyl]acrylon itrile showed potent antispasmodic activities in vitro and in vivo (in mice).