88141-08-6Relevant academic research and scientific papers
Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part 1. Transformation of N,S-acetals: 3-acyl-1,3,4-thiadiazolines
Somogyi, Laszlo
, p. 2243 - 2267 (2004)
Aldehyde and ketone thiosemicarbazones are synthesized and cyclized into 3-acyl-1,3,4-thiadiazolines under acylating conditions. Reactions of the 2-monosubstituted heterocycles with oxidizing and dehydrogenating agents (KMnO4 or for the first time with CAN, DDQ, IBDA) lead to the formation of thiadiazoles. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-thiadiazolines regenerates the parent ketones efficiently.
METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS
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Paragraph 00122, (2020/12/29)
Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment, comprising inhibiting aminolevulinic acid synthase 2 (ALAS2) in the subject by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Disorders that are of particular interest are blood disorders, such as porphyria and anemia.
N-benzyl amino thiourea urease inhibitor and preparation method and application of N-benzyl amino thiourea urease inhibitor
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Paragraph 0027; 0028, (2019/02/26)
The invention discloses a N-benzyl amino thiourea compound, the general structural formula of the N-benzyl amino thiourea compound is shown in the description, the N-benzyl amino thiourea compound hasa better effect on inhibiting urease, and can be used t
