88144-07-4

Basic information

• Product Name: Carbamic acid, [(1S)-2-(hydroxyamino)-1-(hydroxymethyl)-2-oxoethyl]-, phenylmethyl ester
• CAS NO: 88144-07-4
• Molecular Formula: C11H14N2O5
• Molecular Weight: 254.243
• Mol File: 88144-07-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-(hydroxyamino)-1-(hydroxymethyl)-2-oxoethyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-(hydroxyamino)-1-(hydroxymethyl)-2-oxoethyl]-, phenylmethyl ester(88144-07-4)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-(hydroxyamino)-1-(hydroxymethyl)-2-oxoethyl]-, phenylmethyl ester(88144-07-4)

Safety Data

• Hazardous Substances Data: 88144-07-4(Hazardous Substances Data)

Upstream product

• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 

Downstream Products

• 82933-42-4 2-oxo-3-(Cbz-amino)-1-azetidinyl sulfate tetra n-butyl ammonium salt 
• 88144-10-9 N-acetoxy-3-(Cbz-amino)-2-azetidinone 
• 80082-81-1 benzyl N-[(3S)-2-oxoazetidin-3-yl]carbamate 
• 83105-75-3 (3S)-1-hydroxy-3-[[[(phenylmethyl)oxy]carbonyl]amino]-2-azetidinone 
• 88144-08-5 O-acetyl-α-N-Cbz-L-serine hydroxamate 

Relevant articles and documents

Simple one-flask method for the preparation of hydroxamic acids

(Matrix presented) A one-step conversion of carboxylic acids to hydroxamic acids under very mild conditions is described. This simple and efficient method has been applied for the synthesis of enantiopure hydroxamate of α-amino acids and peptides.

Practical synthetic approaches to intermediates for the preparations of the novel O-sulfonated-N-hydroxy-2-azetidinone antibiotics

A practical synthesis of intermediates useful for the preparation of a variety of monocyclic β-lactam antibiotics is described. Hydroxaminolysis of N-protected serine esters provided the hydroxamic acids 10. Acylation followed by cyclization yielded the β