83105-75-3Relevant academic research and scientific papers
Solid-Phase Synthesis of β-Lactams via the Miller Hydroxamate Approach
Meloni, Marco Massimiliano,Taddei, Maurizio
, p. 337 - 340 (2007/10/03)
(Matrix Presented) β-Lactams were prepared on solid phase starting from serine, threonine, or other β-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the β-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, β-lactam-containing peptides were obtained.
Practical synthetic approaches to intermediates for the preparations of the novel O-sulfonated-N-hydroxy-2-azetidinone antibiotics
Miller,Biswas,Krook
, p. 2571 - 2575 (2007/10/02)
A practical synthesis of intermediates useful for the preparation of a variety of monocyclic β-lactam antibiotics is described. Hydroxaminolysis of N-protected serine esters provided the hydroxamic acids 10. Acylation followed by cyclization yielded the β
